Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
The Temporal Expression Of Adipokines During Spinal Fusion, Sohrab Virk, Alicia L. Bertone, Hayam Hamaz Hussein, Jeffrey M. Toth, Mari Kaido, Safdar Khan
The Temporal Expression Of Adipokines During Spinal Fusion, Sohrab Virk, Alicia L. Bertone, Hayam Hamaz Hussein, Jeffrey M. Toth, Mari Kaido, Safdar Khan
Biomedical Engineering Faculty Research and Publications
Background Context
Adipokines are secreted by white adipose tissue and have been associated with fracture healing. Our goal was to report the temporal expression of adipokines during spinal fusion in an established rabbit model.
Purpose
Our goal was to report the temporal expression of adipokines during spinal fusion in an established rabbit model.
Study Design
The study design included a laboratory animal model.
Methods
New Zealand white rabbits were assigned to either sham surgery (n=2), unilateral posterior spinal fusion (n=14), or bilateral posterior spinal fusion (n=14). Rabbits were euthanized 1–6 and 10 weeks out from surgery. Fusion was evaluated by …
Treating A 20 Mm Hg Gradient Alleviates Myocardial Hypertrophy In Experimental Aortic Coarctation, David C. Wendell, Ingeborg Friehs, Margaret M. Samyn, Leanne Harmann, John F. Ladisa
Treating A 20 Mm Hg Gradient Alleviates Myocardial Hypertrophy In Experimental Aortic Coarctation, David C. Wendell, Ingeborg Friehs, Margaret M. Samyn, Leanne Harmann, John F. Ladisa
Biomedical Engineering Faculty Research and Publications
Background
Children with coarctation of the aorta (CoA) can have a hyperdynamic and remodeled left ventricle (LV) from increased afterload. Literature from an experimental model suggests the putative 20 mm Hg blood pressure gradient (BPG) treatment guideline frequently implemented in CoA studies may permit irreversible vascular changes. LV remodeling from pressure overload has been studied, but data are limited following correction and using a clinically representative BPG.
Materials and methods
Rabbits underwent CoA at 10 weeks to induce a 20 mm Hg BPG using permanent or dissolvable suture thereby replicating untreated and corrected CoA, respectively. Cardiac function was evaluated at …