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Full-Text Articles in Biomedical Engineering and Bioengineering
The Temporal Expression Of Adipokines During Spinal Fusion, Sohrab Virk, Alicia L. Bertone, Hayam Hamaz Hussein, Jeffrey M. Toth, Mari Kaido, Safdar Khan
The Temporal Expression Of Adipokines During Spinal Fusion, Sohrab Virk, Alicia L. Bertone, Hayam Hamaz Hussein, Jeffrey M. Toth, Mari Kaido, Safdar Khan
Biomedical Engineering Faculty Research and Publications
Background Context
Adipokines are secreted by white adipose tissue and have been associated with fracture healing. Our goal was to report the temporal expression of adipokines during spinal fusion in an established rabbit model.
Purpose
Our goal was to report the temporal expression of adipokines during spinal fusion in an established rabbit model.
Study Design
The study design included a laboratory animal model.
Methods
New Zealand white rabbits were assigned to either sham surgery (n=2), unilateral posterior spinal fusion (n=14), or bilateral posterior spinal fusion (n=14). Rabbits were euthanized 1–6 and 10 weeks out from surgery. Fusion was evaluated by …
Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid
Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Obesity and related metabolic disorders have reached global epidemic proportions in recent decades. Excess and hypertrophic adipose tissue has been implicated in the development of various pathological diseases and disorders including Type-2 diabetes mellitus (Type-2 DM). In addition to serving as energy storage for the body, evidence also suggests that adipose tissue behaves as an endocrine organ capable of secreting bioactive cytokines known as adipokines, which mediate insulin signaling pathways in various tissues. Physical exercise has been demonstrated to positively affect insulin signaling activities potentially through increasing the secretion of insulin sensitizing adipokines and/or decreasing the secretion of pro-inflammatory insulin …