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Biomedical Engineering and Bioengineering Commons™
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- 7 Tesla MRI (1)
- Biocompatible Materials (1)
- Biomaterial (1)
- Cardiac Volume (1)
- Computer Simulation (1)
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- Elastic Modulus (1)
- Equipment Design (1)
- Finite Element Analysis (1)
- Finite Element Modeling (1)
- Heart Ventricles (1)
- High resoluation imaging (1)
- Hydrogels (1)
- Imaging, Three-Dimensional (1)
- Injections (1)
- Left Ventricular Remodeling (1)
- Magnetic Resonance Imaging (1)
- Materials Testing (1)
- Mitral Valve (1)
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- Models, Anatomic (1)
- Models, Cardiovascular (1)
- Myocardial Infarction (1)
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Articles 1 - 2 of 2
Full-Text Articles in Biomedical Engineering and Bioengineering
Computational Sensitivity Investigation Of Hydrogel Injection Characteristics For Myocardial Support, Hua Wang, Christopher B. Rodell, Madonna E. Lee, Neville N. Dusaj, Joseph H. Gorman Iii, Jason A. Burdick, Robert C. Gorman, Jonathan F. Wenk
Computational Sensitivity Investigation Of Hydrogel Injection Characteristics For Myocardial Support, Hua Wang, Christopher B. Rodell, Madonna E. Lee, Neville N. Dusaj, Joseph H. Gorman Iii, Jason A. Burdick, Robert C. Gorman, Jonathan F. Wenk
Mechanical Engineering Faculty Publications
Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have demonstrated that hydrogel injections can mitigate the adverse remodeling due to MI. More importantly, the material properties of these injections influence the efficacy of the therapy. The goal of the current study is to explore the interrelated effects of injection stiffness and injection volume on diastolic ventricular wall stress and thickness. To achieve this, finite element models were constructed with different hydrogel injection volumes (150 µL and 300 µL), where the modulus was assessed over a range of 0.1 kPa …
High Resolution Imaging Of The Mitral Valve In The Natural State With 7 Tesla Mri, Sam E. Stephens, Serguei Liachenko, Neil B. Ingels, Jonathan F. Wenk, Morten O. Jensen
High Resolution Imaging Of The Mitral Valve In The Natural State With 7 Tesla Mri, Sam E. Stephens, Serguei Liachenko, Neil B. Ingels, Jonathan F. Wenk, Morten O. Jensen
Mechanical Engineering Faculty Publications
Imaging techniques of the mitral valve have improved tremendously during the last decade, but challenges persist. The delicate changes in annulus shape and papillary muscle position throughout the cardiac cycle have significant impact on the stress distribution in the leaflets and chords, thus preservation of anatomically accurate positioning is critical. The aim of this study was to develop an in vitro method and apparatus for obtaining high-resolution 3D MRI images of porcine mitral valves in both the diastolic and systolic configurations with physiologically appropriate annular shape, papillary muscle positions and orientations, specific to the heart from which the valve was …