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Full-Text Articles in Biomedical Engineering and Bioengineering
Densified Collagen-Fibril Biomaterials For Bone Tissue Engineering, Lauren E. Watkins
Densified Collagen-Fibril Biomaterials For Bone Tissue Engineering, Lauren E. Watkins
Open Access Theses
Millions of craniofacial bone defects occur annually as a result of trauma, congenital defects, disease, or tooth extraction. When present in the oral cavity, these defects are associated with adverse impacts on speech, mastication, and aesthetics. Thus, there is a clinical need for interventional strategies to restore and preserve alveolar bone mass to improve the success of future treatment options intended to reestablish functionality and aesthetics. Guided bone regeneration using bone grafts and a membrane represent the current standard of care for repairing alveolar bone defects, but face a number of limitations related to resorption time and structural integrity. Improvements …
An Injectable Stem Cell Delivery System For Treatment Of Musculoskeletal Defects, Shirae Leslie
An Injectable Stem Cell Delivery System For Treatment Of Musculoskeletal Defects, Shirae Leslie
Theses and Dissertations
The goal of this research was to develop a system of injectable hydrogels to deliver stem cells to musculoskeletal defects, thereby allowing cells to remain at the treatment site and secrete soluble factors that will facilitate tissue regeneration. First, production parameters for encapsulating cells in microbeads were determined. This involved investigating the effects of osmolytes on alginate microbead properties, and the effects of alginate microbead cell density, alginate microbead density, and effects of osteogenic media on microencapsulated cells. Although cells remained viable in the microbeads, alginate does not readily degrade in vivo for six months. Therefore, a method to incorporate …
A Fractal-Based Mathematical Model For Cancellous Bone Growth Considering The Hierarchical Nature Of Bone, Stephanie Marie Suhr
A Fractal-Based Mathematical Model For Cancellous Bone Growth Considering The Hierarchical Nature Of Bone, Stephanie Marie Suhr
Browse all Theses and Dissertations
The hierarchical structure of bone alone is not comprehensive enough to provide morphological explanation of how the size and arrangement of the trabeculae within cancellous bone affect load distribution, particularly concerning deterioration of bone in elderly patients. The collagen network and hydroxyapatite play a large role in defining the shape of trabeculae in cancellous bone despite that the arrangement and size is seemingly random. The growth of plates and rods in cancellous bone is mainly due to loading and stress lines within the bone, but mathematical predictive models can be developed using fractal analysis to show how bone may grow …