Biomedical Engineering and Bioengineering Commons^™

Analyzing Surface Protein Expression And Internalization, William Truong, Josergio Zaragoza

Bioengineering Senior Theses

G-protein coupled receptors (GPCRs) are currently the largest class of membrane receptors and are targeted by a majority of the modern drug therapeutics. In addition, they partake in many physiological and pathological processes such as inflammation, growth, and hormone responses. Most importantly, GPCRs are targets of many disease-specific pathways such as Alzheimers, hypertension, leukemia, and depression. As a result, there is an immense interest in studying GPCRs as this area provides further knowledge into the specific disease pathways and allows the discovery of novel therapeutics. In order to have a better understanding of pathways, scientists have studied GPCR activation. The …