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Biomedical Engineering and Bioengineering Commons™
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- Tissue Engineering (2)
- Aortic Heart Valve (1)
- Articular cartilage (1)
- Atomic Force Microscope (1)
- Automobile Driving (1)
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- Bioprosthetic heart valves (1)
- Capacitance measurements (1)
- Cell-Seeding (1)
- Colon targeting (1)
- Compression (1)
- Controlled release (1)
- Dental Pulp (1)
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- Dynamic compression (1)
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- Electrochemistry (1)
- Glycosaminoglycans (1)
- Gold nanoparticles (1)
- Inflammatory Bowel Disease (1)
- Kinematic Chain (1)
- Lower Leg (1)
- MUC1 targeting (1)
- Mitral (1)
- Molecular surface interactions (1)
- Nanoindentation (1)
- Neomycin (1)
- Oral drug delivery (1)
- Pentagalloyl glucose (1)
- Peptide drugs (1)
- Quantifiable motion (1)
Articles 1 - 11 of 11
Full-Text Articles in Biomedical Engineering and Bioengineering
The Effects Of Low Dose Ionizing Radiation Exposure On The Metabolic And Mechanical Properties Of Articular Cartilage, Carl Lindburg
The Effects Of Low Dose Ionizing Radiation Exposure On The Metabolic And Mechanical Properties Of Articular Cartilage, Carl Lindburg
All Theses
Radiation therapy is necessary treatment for many cancer patients due to its non-surgical, yet aggressive and efficacious properties. In fact, over 50% of patients with cancer will undergo some form of radiotherapy during the course of their treatment. While the biological response to ionizing radiation has been examined over the years and many adverse effects have been identified, the effects of radiation on mature cartilage and musculoskeletal tissues are not well understood. Bone, once thought to be a tissue relatively resistant to radiation, has recently been shown to have osteoporosis-like bone atrophy after exposure to low doses (2 Gy) of …
Bioswellable Amphiphilic Copolymers, David Ingram
Bioswellable Amphiphilic Copolymers, David Ingram
All Theses
The suture is one of the most commonly used medical devices, consisting of a fiber, a surgical needle and the packaging in which it is stored. The fiber itself remains after implantation for a defined time and is responsible for the approximation of the wound during the healing process. The needle merely serves to aid in insertion, and preferably has a diameter larger than the diameter of the fiber .
The 1970's marked the birth of a new family of fibrous materials for the approximation of wounds: synthetic absorbable sutures. This family has the ability to provide wound support during …
Effects Of Physiological Dynamic Compression Loading On Gold Nanoparticle Permeation Of Articular Cartilage, Britton Mccaskill
Effects Of Physiological Dynamic Compression Loading On Gold Nanoparticle Permeation Of Articular Cartilage, Britton Mccaskill
All Theses
Articular cartilage is essential part of the human body that aids in support and locomotion. It has unique biochemical and biomechanical properties that allow it to act as a shock absorber to disperse and distribute loading of the joints. However, it has a limited capacity to repair itself because it is not vascularized and must receive its nutrients from the surrounding synovial fluid. Articular cartilage damage can lead to many pathological conditions, including osteoarthritis. Currently, there are many surgical treatment methods that repair some of the damage if it is localized, but for widespread degradation seen in osteoarthritis, there are …
Oral Delivery Of Peptide Drugs For Mitigation Of Crohn's Disease, Paul Blichmann
Oral Delivery Of Peptide Drugs For Mitigation Of Crohn's Disease, Paul Blichmann
All Theses
Protein drugs are typically administered intravenously, but this practice has clear disadvantages such as widespread circulation and swift clearance from the body. Orally delivered protein drugs are not yet available but potentially offer improved distribution, retention, and activity by use of protective matrices and cell-specific targeting. Much work has been done on delayed release formulations for the upper intestine, but there has not been overwhelming evidence of protection of peptides from gastric conditions. In many instances the large intestine may be a better release target due to lower proteolytic activity. Afflictions of the colon such as Inflammatory Bowel Disease and …
The Formulation Of A Bone Targeted Drug Delivery System Of Poly(Glycolic Acid)-Poly(Ethylene Glycol) Coated Hydroxyapatite Nanoparticles For The Delivery Of Statins, Erika Jelen
All Theses
Bone is a form of mineralized connective tissue that provides strength and rigidity to the skeleton. The two primary components within bone tissue are an organic extracellular matrix, containing type I collagen, and an inorganic mineral component composed mainly of calcium phosphate hydroxyapatite crystals. Over time the microarchitecture of bone can break down due to a variety of different factors, mainly the onset of osteoporosis in post-menopausal women, Paget's disease, and the experience of a loss of gravity during space flight. Currently there are about ten million people in the United States alone suffering from osteoporosis.
The prevention of further …
Stabilization Of Extracellular Matrix Components In Bioprosthetic Heart Valves Using Neomycin And Pentagalloyl Glucose Enhanced Crosslinking, Daniel Tripi
All Theses
Bioprosthetic heart valves (BHVs) fail within 12-15 years of implantation due to limited durability. This limits their application to elderly population. Younger patients with contraindications for long-term anticoagulant therapy necessary for mechanical heart valves may also receive BHVs. Investigation into improving valve durability can lead to longer implant life, increased quality of life for patients receiving BHVs, and a broadened patient demographic.
Current BHVs are chemically treated with glutaraldehyde (GLUT) to stabilize collagen via chemical crosslinking and to reduce tissue antigenicity. GLUT fails to adequately stabilize elastin and glycosaminoglycans (GAGs), essential extracellular matrix components for valve function and durability. Degradation …
The Effects Of Coated Gold Nanorods On Porcine Atrioventricular Valve Tissues Using Atomic Force Microscopy, Heather L'Ecuyer
The Effects Of Coated Gold Nanorods On Porcine Atrioventricular Valve Tissues Using Atomic Force Microscopy, Heather L'Ecuyer
All Theses
In this Master's thesis we examine the effect of surface modified gold nanorods (AuNRs) coated with polyelectrolyte multilayers (PEMs) on the mechanical properties of porcine mitral valve tissue ex vivo. The presence of healthy mitral valve tissue in the body is important to ensuring unidirectional flow of blood through the systemic circuit. Unfortunately, due to its anatomic complexity and unique mechanical behavior, pathological mitral valve tissue remains difficult to treat with conventional methods. We hope that the knowledge gleaned from these studies could be useful for developing new and novel treatments treating pathological mitral valve mechanical properties.
Specifically, we examine …
Effects Of Different Microenvironmental Conditions On The Growth And Differentiation Of Dental Pulp Stem Cells, Matthew Cupelli
Effects Of Different Microenvironmental Conditions On The Growth And Differentiation Of Dental Pulp Stem Cells, Matthew Cupelli
All Theses
Human teeth are very complex structures that are susceptible to many different pathologies due to poor dental health. Currently, there are many restorative methods to reestablish some of the function that teeth have, but the materials used in these methods all have drawbacks and cannot fully mimic the native teeth. Tissue engineering research groups have begun to explore regenerating bone or dental tissue using mesenchymal stem cells derived from the bone marrow. However, our group focuses on regenerating dental tissues using multipotent stem cells from dental pulp.
Dental pulp stem cells (DPSCs) have shown similarities to bone marrow stem cells …
Development Of A Lower Extremity Mobility Assessment Methodology For Motor Vehicle Operation And Initial Validation, Justin Arnosky
Development Of A Lower Extremity Mobility Assessment Methodology For Motor Vehicle Operation And Initial Validation, Justin Arnosky
All Theses
Limited quantifiable data exists on lower extremity mobility and function during driving. To date, the most appropriate existing measures of successful driving function are assessed by a driving rehabilitation specialist during an on-road evaluation. Establishing the kinematic chain- or the order and magnitude in which joints are moved- during driving may prove to be a useful tool in lower extremity function assessment in drivers. To this end, a study was conducted instrumenting both the left and right legs of healthy licensed male drivers (18-26 years old) with a system of angle measuring goniometers (Biometrics, Ltd.) in a driving simulator (DriveSafety …
Electrochemical Capacitance Measurements To Study Molecular Surface Interactions, Nrutya Madduri
Electrochemical Capacitance Measurements To Study Molecular Surface Interactions, Nrutya Madduri
All Theses
The behavior of biological molecules such as proteins at the electrode/electrolyte has been of considerable interest for the development of biosensors. Several investigative techniques including Potentiometry, Voltammetry, Amperometry, and Electrochemical Impedance Spectroscopy are being employed to study and analyze these molecular surface interactions. Investigative techniques such as cyclic voltammetry involve the application of a large potential to probe the electrode characteristics and capture the bulk membranous events to obtain the required measurements. This study looks to achieve two major objectives through the use of a novel technique, namely, the double layer capacitive method: 1) to analyze the electrochemical behavior of …
Dynamic Endothelialization Of Aortic Heart Valve Scaffolds, Richard Pascal
Dynamic Endothelialization Of Aortic Heart Valve Scaffolds, Richard Pascal
All Theses
Cardiovascular disease is the number one killer worldwide affecting both the heart and blood vessels. Valvular heart disease can arise from calcification, and structural deterioration resulting in a stenotic or regurgitant valve incapable of proper function. With approximately 275,000 valve replacements performed annually worldwide, the need for replacement heart valves is well established. Currently, treatment of valvular heart disease is limited to two options (mechanical and bioprosthetic). Both replacement valves have their own drawbacks, which have driven research in the bioengineering field to focus on the development of a tissue engineered heart valve (TEHV) capable of growth and self-repair.
A …