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Full-Text Articles in Biomedical Engineering and Bioengineering
Characterization And Implementation Of Low Intensity Pulsed Ultrasound As A Tool To Apply Physical Load To Scaffolds And Bone Cells For Fracture Repair, Scott Frazee
Master's Theses
One current challenge in treating bone fractures is the effective treatment of non-unions and delayed unions. Low Intensity Pulsed Ultrasound (LIPUS) has been approved by the FDA to treat fresh fractures since 1994 and non-unions since 2000 and is an attractive treatment option because it is non-invasive. The mechanism by which it works, however, is not well understood; what is known is largely confined to the resultant changes in chemical output of cells. In this thesis several concepts and techniques were brought together to investigate the following hypothesis: LIPUS produces a measurable physical load that results in measurable deformation and …