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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Directed Cellular Self-Assembly To Fabricate Cell-Derived Tissue Rings For Biomechanical Analysis And Tissue Engineering, Kristen Billiar, Tracy Gwyther, Jason Hu, Marsha Rolle
Directed Cellular Self-Assembly To Fabricate Cell-Derived Tissue Rings For Biomechanical Analysis And Tissue Engineering, Kristen Billiar, Tracy Gwyther, Jason Hu, Marsha Rolle
Kristen L. Billiar
Each year, hundreds of thousands of patients undergo coronary artery bypass surgery in the United States.1 Approximately one third of these patients do not have suitable autologous donor vessels due to disease progression or previous harvest. The aim of vascular tissue engineering is to develop a suitable alternative source for these bypass grafts. In addition, engineered vascular tissue may prove valuable as living vascular models to study cardiovascular diseases. Several promising approaches to engineering blood vessels have been explored, with many recent studies focusing on development and analysis of cell-based methods.2-5 Herein, we present a method to rapidly self-assemble cells …
Methods Development And Force Field Evaluation For Molecular Simulations Of Interactions Between Structured Peptides And Functionalized Material Surfaces, Galen Collier
All Dissertations
The process of protein adsorption to material surfaces is highly complex and it is one of the most fundamental concepts upon which progress in the field of bioengineering is based. The strategic design of material surfaces for optimal utility in specific biological environments is absolutely dependent upon a thorough understanding of the mechanisms underlying protein adsorption, yet there is still a very limited understanding of these mechanisms. The primary reason for this lack of understanding is that protein adsorption is a dynamic process which occurs at the atomic and macromolecular scale, where experimental analyses provide a view that is static …
Characterising 3d Soft Tissue Features On Joint Surfaces, Colm O'Kane
Characterising 3d Soft Tissue Features On Joint Surfaces, Colm O'Kane
Conference Papers
A crucial aspect of orthopaedic implant design is the prediction of surgical outcomes when the shape of a bone is necessarily altered by the addition of the implant. Matching native kinematics as closely as possible is generally considered a core aim of joint replacement surgery. The overall hypothesis behind this research is that soft tissue geometry, including cartilage thickness distribution and ligament attachment sites, influences kinematics in the knee joint. In order to enable investigation of possible links between geometry and kinematics, the ability to characterise the shape variation of the soft tissue relative to the underlying bony geometry must …
Characterising 3d Soft Tissue Features On Joint Surfaces, Colm O'Kane
Characterising 3d Soft Tissue Features On Joint Surfaces, Colm O'Kane
Other resources
A crucial aspect of orthopaedic implant design is the prediction of surgical outcomes when the shape of a bone is necessarily altered by the addition of the implant. Matching native kinematics as closely as possible is generally considered a core aim of joint replacement surgery. The overall hypothesis behind this research is that soft tissue geometry, including cartilage thickness distribution and ligament attachment sites, influences kinematics in the knee joint. In order to enable investigation of possible links between geometry and kinematics, the ability to characterise the shape variation of the soft tissue relative to the underlying bony geometry must …