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Full-Text Articles in Biomedical Engineering and Bioengineering
Electrospun Scaffolds For Directed Pancreatic Differentiation Of Human Ips Cells, Karl Sonntag
Electrospun Scaffolds For Directed Pancreatic Differentiation Of Human Ips Cells, Karl Sonntag
Biological and Agricultural Engineering Undergraduate Honors Theses
In this work, an electrospinning device for fabricating three-dimensional scaffolds was constructed. The device can be used to produce tissue engineered scaffolds electrospun for directing the differentiation of human induced pluripotent stem (iPS) cells into glucose-responsive, insulin-secreting cells for diabetes treatment. Electrospinning utilizes high electrical charge to generate nanofibers from polymers dissolved in solution. A standard setup for such a device includes a high-voltage power source, a syringe pump, and a grounded collector. The process works by dissolving the polymer in a volatile solvent, and filling a syringe with the polymer/solvent mixture. Next, the syringe is locked into place in …
In-Vivo Testing Of Vertically Aligned Nanowire Implantable Titanium Electrodes In The Rattus Norvegicus Hippocampus, Lauren Kegley
In-Vivo Testing Of Vertically Aligned Nanowire Implantable Titanium Electrodes In The Rattus Norvegicus Hippocampus, Lauren Kegley
Inquiry: The University of Arkansas Undergraduate Research Journal
Miniaturized multielectrode arrays are MEMS devices that have found use as neural prosthetics (Neuro-MEMS). As implants, they can interface with neurons as sensors or actuators and help compensate for loss of sensory input, motor control, or cognitive functions. The microelectrodes studied here were developed in-house. They have a vertically aligned gold nanowire array and are mounted on a sturdy titanium needle with a fine gauge. Hence, the bill of materials and design characteristics encourage their use as a neural probe. For this study, a probe was tested in vivo for signal acquisition in the hippocampus of a Rattus Norvegicus (Sprague …