Biomedical Engineering and Bioengineering Commons^™

Fabrication Of Bioactive Osteogenic Controlled-Release Systems, Cellular Platforms, And Cellular Capsules Using Layer -By -Layer Nanoassembly, Skylar Stewart-Clark

Doctoral Dissertations

There is an ever-increasing awareness that the field of tissue engineering offers many potential solutions to clinical problems. While advances along these lines have been made, the design and implementation of an "off the shelf" tissue is yet to be realized. Thus, the objectives of this work were largely aimed at the design and fabrication of biocompatible, bioactive structures which could be integrated into existing biomaterial products.

The electrostatic layer-by-layer (LbL) self-assembly technique was used to incorporate biologically relevant molecules within controlled release systems, cell culture platforms, and 3-D cellular capsules. Two delivery systems were investigated to determine the release …