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Full-Text Articles in Biomedical Engineering and Bioengineering
Spontaneous Planarization Of Nanoscale Phase Separated Thin Film, Ravi F. Saraf, Sanjun Niu, Eric Stumb
Spontaneous Planarization Of Nanoscale Phase Separated Thin Film, Ravi F. Saraf, Sanjun Niu, Eric Stumb
Ravi Saraf Publications
Structure of complex fluid at mesoscales is influenced by interfacial effects. We describe the dynamic response in such films to sudden change in interfacial tension. In a self-assembled block copolymer film, the monolayer of 15 nm diam cylindrical discrete phases close to the surface commence to sink at an average rate of 0.16 nm/day in response to the interfacial tension change. Surprisingly, this spontaneous planarization occurs, even though the cylinders are covalently stitched to the matrix. A simple model explains the observed behavior. The observation may lead to approaches to tailor the structure of mesoscale thin films of complex fluids …
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
An Approach To Sequence Dna Without Tagging, Sanjun Niu, Ravi F. Saraf
Ravi Saraf Publications
Microarray technology is playing an increasingly important role in biology and medicine and its application to genomics for gene expression analysis has already reached the market with a variety of commercially available instruments. In these combinatorial analysis methods, known probe single-strand DNA (ssDNA) “primers” are attached in clusters of typically 100 μm × 100 μm pixels. Each pixel of the array has a slightly different sequence. On exposure to “unknown” target ssDNA, the pixels with the right complementary probe ssDNA sequence convert to double-stranded DNA (dsDNA) by a hybridization reaction. To transduct the conversion of the pixel to dsDNA, the …