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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 8 of 8
Full-Text Articles in Biomedical Engineering and Bioengineering
Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso
Longitudinal Monitoring Of Tumor Response To Immune Checkpoint Inhibitors Using Diffuse Optical Spectroscopy, Joel Isaac Rodriguez Troncoso
Graduate Theses and Dissertations
Immune checkpoint drugs have completely changed the way people treat metastatic melanoma and non-small-cell lung cancer. While the impacts of these immunological checkpoints and their suppression on T cell function are well characterized, their consequences on the tumor microenvironment are not. In a CT26 mouse colorectal cancer model, we employed diffuse reflectance spectroscopy to track in vivo tumor microenvironmental alterations in response to immune checkpoint inhibitors. On three separate days, animals bearing CT26 tumor xenografts were given anti-PD-L1, anti-CTLA-4, a combination of both inhibitors, and isotype control. Within the first 6 days, monotherapy with either anti-PD-L1 or anti-CTLA-4 resulted in …
Multiphoton Microscopy And Deep Learning Neural Networks For The Automated Quantification Of In Vivo, Label-Free Optical Biomarkers Of Skin Wound Healing, Jake D. Jones
Graduate Theses and Dissertations
Non-healing ulcerative wounds that occur frequently in diseases such as diabetes are challenging to diagnose and treat due to numerous possible etiologies and the variable efficacy of wound care products. With advanced age, skin wound healing is often delayed, leaving elderly patients at high risk for developing these chronic injuries. As it is challenging to discriminate age-related delays from disease-related chronicity, there is a critical need to develop new quantitative biomarkers that are sensitive to wound status. Multiphoton microscopy (MPM) techniques are well-suited for 3D imaging of epithelia and are capable of non-invasively detecting metabolic cofactors (NADH and FAD) without …
In Vivo Data Capture Using Hssr For Calibration Of Computational Models, Thor Erik Andreassen
In Vivo Data Capture Using Hssr For Calibration Of Computational Models, Thor Erik Andreassen
Electronic Theses and Dissertations
Computational modeling is a vital tool for understanding and evaluating healthy and unhealthy function of the musculoskeletal aspects of the human body. However, the accuracy of the musculoskeletal models depends significantly on the accuracy of the input data used to calibrate various behavioral parameters of the model. To date, most computational models have been built using generic in vitro data, mostly because of a lack of accurate and meaningful datasets from in vivo testing. The next major step in computational modeling is to create subject-specific computational models using calibration data taken from in vivo testing. The overall goal was to …
Characterization Of Structural Dynamics Of The Human Head Using Magnetic Resonance Elastography, Andrew Arun Badachhape
Characterization Of Structural Dynamics Of The Human Head Using Magnetic Resonance Elastography, Andrew Arun Badachhape
McKelvey School of Engineering Theses & Dissertations
In traumatic brain injury (TBI), the skull-brain interface, composed of three meningeal layers: the dura mater, arachnoid mater, and pia mater, along with cerebrospinal fluid (CSF) between the layers, plays a vital role in transmitting motion from the skull to brain tissue. Magnetic resonance elastography (MRE) is a noninvasive imaging modality capable of providing in vivo estimates of tissue motion and material properties. The objective of this work is to augment human and phantom MRE studies to better characterize the mechanical contributions of the skull-brain interface to improve the parameterization and validation of computational models of TBI. Three specific aims …
An In Vivo Study Of The Effects Of Perinatal Caffeine Exposure On Synaptic Efficacy In The Hippocampus Of Freely Moving Adult Rats, Jee Eun Park
Senior Theses and Projects
The synapse from the perforant path to the dentate gyrus has been widely used successfully to demonstrate long-term potentiation, a cellular model underlying learning and memory. Caffeine is one of the most widely consumed psychoactive stimulants in the world. Caffeine consumption increases in alertness, improvements in motor skills, and neurological functions, and these effects have promoted its use throughout history. Although the many short term cognitive benefits of caffeine intake are well understood, the long term effects of caffeine exposure have been widely disputed. Despite this, it is estimated that over 80% of women continue to consume caffeine throughout pregnancy. …
Healing Of Bone Defects In A Rodent Calvarial Defect Model Using Strong Porous Bioactive Glass (13-93) Scaffolds, Yinan Lin
Masters Theses
"The main objective of this project was to evaluate the capacity of strong porous silicate (13-93) bioactive glass scaffolds prepared by a robocasting technique to regenerate bone and stimulate angiogenesis in a rat calvarial defect model. The scaffolds were created with the same grid-like microstructure but in a variety of formulations: (i) as-fabricated, (ii) pretreated in an aqueous phosphate solution to convert the glass surface to hydroxyapatite, (iii) loaded with bone morphogenetic protein-2 (BMP2) (1 µg per scaffold), and (iv) doped with copper (0.4-2.0 wt. % CuO). When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at …
Biocorrosion Rate And Mechanism Of Metallic Magnesium In Model Arterial Environments, Patrick Bowen
Biocorrosion Rate And Mechanism Of Metallic Magnesium In Model Arterial Environments, Patrick Bowen
Dissertations, Master's Theses and Master's Reports
A new paradigm in biomedical engineering calls for biologically active implants that are absorbed by the body over time. One popular application for this concept is in the engineering of endovascular stents that are delivered concurrently with balloon angioplasty. These devices enable the injured vessels to remain patent during healing, but are not needed for more than a few months after the procedure. Early studies of iron- and magnesium-based stents have concluded that magnesium is a potentially suitable base material for such a device; alloys can achieve acceptable mechanical properties and do not seem to harm the artery during degradation. …
Characterization Of Potential Wear Sources In Knee Arthroplasty Prostheses After In Vivo Function, Nicole Durig
Characterization Of Potential Wear Sources In Knee Arthroplasty Prostheses After In Vivo Function, Nicole Durig
All Theses
Total joint arthroplasty (TJA) is a common procedure generally performed in patients with osteoarthritis. While TJA continues to be a successful treatment for degenerative joint disease, there are many studies that demonstrate wear and its sequelae as the major limitation of joint replacement longevity. Previous studies have shown that wear debris originates from four main locations: articulating surfaces, modular component surfaces, surfaces of fixation, and adjuvant fixation devices. Each of these possible wear sources can initiate the cascade of failure associated with wear-induced osteolysis and lead to subsequent revision surgery. The objective of this thesis is to characterize the in …