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Articles 1 - 11 of 11
Full-Text Articles in Biomedical Engineering and Bioengineering
A Novel Approach To Mid-Foot Reconstruction Surgery In Patients With Charcot Arthropathy, Jessi Martin, Deborah Falokun
A Novel Approach To Mid-Foot Reconstruction Surgery In Patients With Charcot Arthropathy, Jessi Martin, Deborah Falokun
Williams Honors College, Honors Research Projects
This honors project details the design and development of an internal orthopedic implant that surgically corrects the midfoot fracture and subsequent arch collapse in patients with Charcot arthropathy. The client of the project is Dr. David Kay, an orthopedic surgeon with the Crystal Clinic in Akron, Ohio. He presented a problem surrounding surgical implants meant to repair Charcot arthropathy. Implants that repair the midfoot fracture failed at a rate of about 60%. A team of senior biomedical engineering students attending the University of Akron developed a goal to design a new surgical implant that would reduce the failure rate of …
Fabrication And In Vitro Characterization Of An Implant For The Detection Of Metastatic Cancer Cells, Carlos Martin Cantu
Fabrication And In Vitro Characterization Of An Implant For The Detection Of Metastatic Cancer Cells, Carlos Martin Cantu
Bioengineering Theses
Greater than 90% of cancer related deaths are due to metastasis (Hayes & Wicha, 2011). Since current conventional techniques detect the disease by the time that it has become systemic, our lab has developed a hydrogel based cancer trap that can attract metastatic cancer cells via cytokine release. However, for continual monitoring and accessibility to the gel, an implant is needed for delivery, retention, and retrieval of the gel. The research undergone in this thesis seeks to develop such a method. Namely, the objective was to develop a polylactide (PLA) based implant that is capable of delivering and retaining a …
Cementless Tibial Base Micromotion During Activities Of Daily Living, Hayden Wilson
Cementless Tibial Base Micromotion During Activities Of Daily Living, Hayden Wilson
Electronic Theses and Dissertations
Initial stability of cementless total knee replacement (TKR) components is directly related to long-term fixation and success, as excess motion hinders bony ingrowth. To assess implant stability, there is a need for more physiologically accurate loading conditions, incorporating forces and displacements in all 6 degrees-of-freedom found in the knee joint, as well as understanding the impact of femoral flexion on conformity of tibiofemoral articulation. Understanding how different activities of daily living generate tibial micromotion yields insight into surgical technique considerations, and rehabilitation strategies post-operatively. ASTM F3141-15, which specifies knee flexion, Internal-External moment, Medial-Lateral, Anterior-Posterior and Superior-Inferior forces during gait and …
Engineering Surface Properties To Modulate Inflammation And Stem Cell Recruitment Through Macrophage Activation, Kelly M. Hotchkiss
Engineering Surface Properties To Modulate Inflammation And Stem Cell Recruitment Through Macrophage Activation, Kelly M. Hotchkiss
Theses and Dissertations
Biomaterials are becoming the most commonly used therapeutic method for treatment of lost or damaged tissue in the body. Metallic materials are chosen for high strength orthopaedic and dental applications. Titanium (Ti) implants are highly successful in young, healthy patients with the ability to fully integrate to surrounding tissue. However the main population requiring these corrective treatments will not be healthy or young, therefore further research into material modifications have been started to improve outcomes in compromised patients. The body’s immune system will generate a response to any implanted material, and control the final outcome. Among the first and most …
A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections, Salil Sidharthan Karipott
A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections, Salil Sidharthan Karipott
Dissertations, Master's Theses and Master's Reports
Sensorized implants with embedded wireless, passive temperature sensors were developed for early detection of implant-associated infections. The operation principle of the sensor is based on the hypothesis that infections can lead to an increase in local temperature prior to the rise of body temperature. The sensor was an inductive capacitive (LC) circuit that has been used for monitoring of different parameters wirelessly, often in difficult to access environments. The sensor was fabricated on to an interference screw, which is used for tendon and ligament reconstruction surgeries. In this project, a sensorized interference screw was designed and fabricated by accommodating an …
A Rubric For Electrochemical Testing Of Metallic Biomaterials, Frederick G. De La Fuente
A Rubric For Electrochemical Testing Of Metallic Biomaterials, Frederick G. De La Fuente
Master's Theses
Corrosion is a major factor for the failure of metallic medical implants. Testing a metal’s suseptability to corrosion prior to implantation is key to a successful implantation. Electrochemical processes were used in this study to evaluate the characteristics of corrosion of both AISI 316 stainless steel and titanium alloy Ti6Al4V, welded and non-welded. Linear, potentiodynamic, and cyclic polarization curves were produced by the PARC 2273 potentiostat showing the corrosion tendencies of the metals in four unique solutions 3.5% NaCl, 0.35% NaCl, phosphate buffered saline solution (PBS), and Butterfield phosphate buffered solution (BPS). The concentration of chloride ions in solutions affected …
Development Of A Gel Content Analysis Protocol For Ultra High Molecular Weight Polyethylene, Max Harold Jeanty
Development Of A Gel Content Analysis Protocol For Ultra High Molecular Weight Polyethylene, Max Harold Jeanty
Theses
A modified procedure based upon ASTM (D 2765 - 90) to determine the gel content of crosslinked polyethylene plastics was developed. The new procedure was applied to ram extruded Ultra High Molecular Weight (UHMWPE) implant components processed under different manufacturing conditions. This new evaluation tool provides consistent results with greater accuracy and consistency compared to the American Society for the Testing of Materials (ASTM) method. Using the same tool, several relationships between the UHMWPE processing conditions and gel content were established. The amount of gel content is related to the crosslinked material. It has been shown that the more crosslinking …
The Morphology Of Uhmwpe Wear Debris Generated By A Hip Joint Simulator, Aaron P. Essner
The Morphology Of Uhmwpe Wear Debris Generated By A Hip Joint Simulator, Aaron P. Essner
Theses
The size, quantity and shape of total hip replacement wear debris may identify wear mechanisms as well as play a role in osteolysis. Characterization of wear particles generated from a hip joint simulator was conducted followed by comparison with literature reported in vivo results. The effect of counterface material and lubricant type on particle morphology was assessed. Biomaterial pairs including UHMWPE articulated against CoCr, Alumina and Zirconia were considered. Deionized (D.I.) water and bovine serum were used as lubricants. Particles generated from Alumina/UHMWPE in serum were slightly larger than those for CoCr and Zirconia against UHMWPE in serum. Particle shape …
Wear And Friction Of Hylamer And Polyethylene Against Cobalt Chromium A Pin-On-Disc Study, Jerry D'Alessio, Ii
Wear And Friction Of Hylamer And Polyethylene Against Cobalt Chromium A Pin-On-Disc Study, Jerry D'Alessio, Ii
Theses
Understanding friction and wear of biomaterials is essential to the success of any prosthetic joint. A pin-on-disc wear tester is used to find the friction and wear of pins of one material on a coupon of medical grade cobalt chrome. In this experiment six pins of UHMWPe (ultra high molecular weight polyethylene) and six pins of Hylamer® from Du Pont Manufacturing were tested. Four separate runs were made. The tests were performed for ten million cycles, stopping every one to one and a half million cycles for data acquisition. Volumetric wear, wear rate, and coefficients of friction were measured. Both …
Wear Of Polyethylene And Hylamer On Cobalt-Chromium : A Knee Simulator Study, Alessandro F. Canonaco
Wear Of Polyethylene And Hylamer On Cobalt-Chromium : A Knee Simulator Study, Alessandro F. Canonaco
Theses
Two tests were conducted to examine the wear characteristics of tibial bearings used in total knee replacement systems. Each test consisted of six A/P Glide Tibial Bearings each having a conical control arm. The plastic portion of the conical bearings were all made of UHMWPe. Each of these bearing systems was mounted onto a Co-Cr alloy tibial platform and Co-Cr alloy LCS (low contact stress) femoral component . These test samples were mounted onto the New Jersey Mark III Knee Simulator System. The simulator was configured to produce flexion and axial rotation to simulates normal gait. Each test ran at …
Wear And Friction Of Titanium Nitride On Ultra High Molecular Weight Polyethylene Under Oscillating Motion For Evaluation Of Use In Articulating Orthopedic Applications, David Scott Jacobson
Wear And Friction Of Titanium Nitride On Ultra High Molecular Weight Polyethylene Under Oscillating Motion For Evaluation Of Use In Articulating Orthopedic Applications, David Scott Jacobson
Theses
Materials are a factor in the performance of articulating orthopedic implants. An oscillating tribometer is utilized to investigate mechanisms of wear and friction of TiN (titanium nitride) coated on Ti-6Al-4V (titanium) alloy against UHMWPe (ultra high molecular weight polyethylene). Three thicknesses of TiN coating (1.76 pm, 4.15 µm, and 10.5 µm) are used to evaluate the performance of each in UHMWPe wear reduction and coating integrity. An uncoated Co-Cr (cobalt chromium) coupon is used against UHMWPe pins for control purposes. Oscillations are carried out to 10 million cycles to discover and evaluate short- and long-term wear mechanisms. Mass differentials and …