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Articles 61 - 63 of 63
Full-Text Articles in Biomedical Engineering and Bioengineering
Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold
Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold
Theses
Electrospinning processes apply electric fields to a polymer solution in order to produce strands of polymer in the nanoscale range. These polymer fibers are manipulated for their porosity, high surface area, fineness and uniformity. In order to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were analyzed to obtain the prime base for drug annexation. 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, …
Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram
Fabrication Of Nanofiber Scaffolds By Electrospinning And It's Potential For Tissue Engineering, Shobana Shanmugasundaram
Theses
Electrospinning is a fabrication process that uses an electric field to control the deposition of polymer fibers on to a target substrate. This electrospinning strategy can be used to fabricate fibrous polymer mats composed of fiber diameters ranging from several microns down to tens of nanometers. This study assesses the potential of electrospinning, as an alternative scaffold fabrication technique for tissue engineering applications. In this study, electrospinning is adapted to produce tissue-engineering scaffolds of two different size ranges composed of non-woven poly-L-lactide (PLLA) nanofibers and as a first study, the potential use of these scaffolds as tissue engineering scaffolds was …
Electrospinning As A Processing Method For Electroactive Polymers And Composites, Kristin Joy Pawlowski
Electrospinning As A Processing Method For Electroactive Polymers And Composites, Kristin Joy Pawlowski
Theses and Dissertations
Electrospinning was examined for its potential to create functional materials. Three distinct electroactive materials were electrospun into fibers and fiber mats and then characterized with the intent of determining their utility in aerospace and biomedical applications such as micro-air vehicles and the cardiovascular system. Electrospun Graft Elastomers demonstrated potential as actuators, as electromechanical strain testing showed comparable response to the film form of this material. Further improvement of electroactive response was realized with high dielectric inclusions and fiber orientation. Electrospin processing imparted piezoelectric properties to the fibers of poly(vinylidene fluoride). Differential scanning calorimetry and infrared spectroscopy indicated a degree of …