Biomedical Engineering and Bioengineering Commons^™

Drug Delivery To The Respiratory Tract Using Dry Powder Inhalers, Doaa M.R. Mossaad

Electronic Thesis and Dissertation Repository

Aerosols are an effective method to deliver therapeutic agents to the respiratory tract. Among aerosol generation systems, dry powder inhales have been attractive area of research for both local and systemic delivery of drugs. The challenge of any inhalation delivery system is to generate particles with an adequate range of particle sizes. In order to advance powder aerosol technologies, researchers have recognized the importance of investigating determinants affecting powder dispersion. The effect of particles’ surface characteristics, inhalation airflow rate, inhalation device, and development of an effective drug-carrier system are some of the fundamental areas that have been under investigation.

The …

Additives To Control Mechanical Properties And Drug Delivery Of Injectable Polymeric Scaffolds, Paul Fisher

Theses and Dissertations--Biomedical Engineering

In situ forming implants (ISIs) are popular due to their ease of use and local drug delivery potential, but they suffer from high initial drug burst, and release behavior is tied closely to solvent exchange and polymer properties. Additionally, such systems are traditionally viewed purely as drug delivery devices rather than potential scaffold materials due to their poor mechanical properties and minimal porosity. The aim of this research was to develop an injectable ISI with drug release, mechanical, and microstructural properties controlled by micro- and nanoparticle additives.

First, an injectable ISI was developed with appropriate drug release kinetics for orthopedic …

Studies Of Functionalized Nanoparticles For Smart Self-Assembly And As Controlled Drug Delivery, Xiaochu Ding

Dissertations, Master's Theses and Master's Reports - Open

This dissertation is related to the studies of functionalized nanoparticles for self-assembly and as controlled drug delivery system. The whole topic is composed of two parts. In the first part, the research was conducted to design and synthesize a new type of ionic peptide-functionalized copolymer conjugates for self-assembly into nanoparticle fibers and 3D scaffolds with the ability of multi-drug loading and governing the release rate of each drug for tissue engineering. The self-assembly study confirmed that such peptide-functionalized amphiphilic copolymers underwent different self-assembly behavior. The bigger nanoparticles were more easily assembled into nanoparticle fibers and 3D scaffolds with larger pore …

Growth Plate Regeneration Using Polymer-Based Scaffolds Releasing Growth Factor, Amanda Clark

Theses and Dissertations--Biomedical Engineering

Currently growth plate fractures account for nearly 18.5% of fractures in children and can lead to stunted bone growth or angular deformation. If the body is unable to heal itself a bony bar forms, preventing normal bone growth. Clinical treatment involves removing the bony bar and replacing it with a filler substance, which causes poor results 60% of the time.

Using primarily poly(lactic-co-glycolic acid) (PLGA) as the scaffold material, the goal was to develop an implant that would support to the implant site, allow for cell ingrowth, and degrade away over time. Porous scaffolds were fabricated from PLGA microspheres using …