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The Role Of Subunit Iii In The Functional And Structural Regulation Of Cytochrome C Oxidase In Rhodobacter Spheroids, Khadijeh Salim Alnajjar
The Role Of Subunit Iii In The Functional And Structural Regulation Of Cytochrome C Oxidase In Rhodobacter Spheroids, Khadijeh Salim Alnajjar
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Cytochrome c oxidase (COX) catalyzes the oxidation of ferrocytochrome c and the reduction of oxygen to water while concomitantly translocating protons across the inner mitochondrial membrane. The catalytic core of COX consists of three subunits that are conserved from the bacterial to the mitochondrial forms of the enzyme. Subunits I and II (SUI and SUII) contain the metal centers where electrons are transferred and oxygen binds for reduction. Subunit III (SUIII) does not contain any metals and has an unknown function. It contains three conserved histidine residues (3, 7 and 10) that are surface exposed and are in close proximity …