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Rapid, Large-Scale Production Of Full-Length, Human-Like Monoclonal Antibodies, Christopher M. Warner
Rapid, Large-Scale Production Of Full-Length, Human-Like Monoclonal Antibodies, Christopher M. Warner
KGI Theses and Dissertations
Current recombinant protein production systems require several months to develop. Existing systems fail to provide timely, flexible, and cost-effective therapies to protect against emergency mass-casualty infections or poisonings. As the identity of many new biological threat agents are unlikely to be known in advance, pre-emptive manufacturing and stockpiling of countermeasures cannot be performed. Preparedness for a biological catastrophe requires a radical solution to replace the current slow scale-up and manufacture of lifesaving medical countermeasures. Subunit vaccines and antibody fragments may be produced in bacteria, yeast, plant or insect cells. However, generation of full-length, human like glycosylated antibodies requires mammalian cell …