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Full-Text Articles in Biomedical Engineering and Bioengineering
Can Spr Be Used To Interrogate The Double Layer Of Nacl, Brandon Kawula
Can Spr Be Used To Interrogate The Double Layer Of Nacl, Brandon Kawula
Biomedical Engineering
Solutions of reagent grade salt .1, .01, .001, .0001, .00001M were run through a SPR to see if SPR had enough resolution to detect the formation of the electric double layer. We found that NaCl did in fact return a detectable signal. The signal shape seems to depend on concentration. While more study may need to be done to get definite information it looks like SPR can interrogate the double layer.
Integration Of Microfluidics With Surface Plasmon Resonance, Scott B. Fratzke
Integration Of Microfluidics With Surface Plasmon Resonance, Scott B. Fratzke
Master's Theses
This thesis successfully integrates laminate microfluidic devices with an analytic Surface Plasmon Resonance (SPR) instrument. Integration was accomplished at low-cost using materials such as polydimethylsiloxane (PDMS), Poly(methyl methacrylate) (PMMA), Tygon tubing, and a 3-way stopcock. The main components of this thesis are the design and fabrication of the low-cost, in-house fluidics that can integrate with upstream microfluidics and the validation of the in-house fluidics using the Biosensing Instruments BI-2000 SPR instrument. The low-cost fluidics was designed and fabricated “in-house” using a novel investment casting technique that required the use of laser cutting technology to make a master cast, and candle …