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Quantitative Estimation Of Heparin Content On Biological Pericadium Tissue Using In Vitro Anti-Factor Xa Assay, Jean-Claude Simeon
Quantitative Estimation Of Heparin Content On Biological Pericadium Tissue Using In Vitro Anti-Factor Xa Assay, Jean-Claude Simeon
Theses
Shelhigh Inc. (Millburn, NJ) has developed a new heparin binding technique to biological tissues. The technique seems to bind heparin to tissues in a more permanent fashion. Shelhigh's heparinized biological tissues are intended for use in long term implants. This investigation was undertaken to assess whether heparin leaching is prevalent when tissues are quarantine for long shelflife at room temperature, whether tissues maintained thromboresistance properties when in contact with plasma and to estimate heparin content of the tissues.
The study used anti-factor Xa assaying methods: clotting time and chromogenic factor Xa sensitive substrate in order to fulfill the aforementioned objectives. …