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Full-Text Articles in Biomedical Engineering and Bioengineering

Model And Clinical Device Development For Noninvasive Diagnosis Of Low Back Pain And Dysfunction, Ravi Patraju Dec 1998

Model And Clinical Device Development For Noninvasive Diagnosis Of Low Back Pain And Dysfunction, Ravi Patraju

Theses

Millions of people suffer from acute or chronic low back pain. In order for proper treatment to be administered, a patient must receive an accurate diagnosis. Therefore, it is critical to develop an objective model to measure the motion and any dysfunction of a patient's low back. Only then can a physician effectively implement the correct therapy and measure its effectiveness through follow-up to minimize or eliminate low back pain.

Numerous cadaveric, active and passive studies have been done to understand the mechanics of low back disorders. However, only living human subjects suffer from low back pain and therefore ...


Measurement Of The Baroreceptor Sensitivity Index (Brsi) In The Frequency Domains, Tanvir Raquib Aug 1998

Measurement Of The Baroreceptor Sensitivity Index (Brsi) In The Frequency Domains, Tanvir Raquib

Theses

Time domain analysis for calculating the Baroreceptor Sensitivity Index (BRSI) did not always provide an accurate result. It also had another limitation in that it could not show the influence of the autonomic nervous system for different subjects. The correlation coefficient is a mechanism that was used to either accept or reject the BRSI values in the time domain but the correlation coefficient values changed drastically depending on how many sample points were selected for the calculation.

On the other hand, frequency domain analysis for the BRSI calculation was relatively easier and provided more accurate information compared to the time ...


Analysis Of Multi-Lead Qt Dispersion By Means Of An Algorithm Implemented On Labview, Zafer Sahinoglu Aug 1998

Analysis Of Multi-Lead Qt Dispersion By Means Of An Algorithm Implemented On Labview, Zafer Sahinoglu

Theses

QT dispersion measurement is significant in diagnostic ECG, and several methods are proposed in the literature to implement QT measurement.

This study consists of two parts: The first part was the development of an algorithm to measure both QT interval and QT dispersion. To check the reliability of the algorithm, 25 single channel ECGs were recorded and their QT intervals were computed. On two subjects, three and four lead ECG data were recorded respectively and their QT dispersions were statistically analyzed. Another part of this study dealt with the effect of the electric dipole of the heart on QT dispersion ...


Development Of A Practical And Effective Technique To Determine The Complete Level Of Autonomic Neural Activity During Stress, Vikki Hazelwood May 1998

Development Of A Practical And Effective Technique To Determine The Complete Level Of Autonomic Neural Activity During Stress, Vikki Hazelwood

Theses

Clinical evidence exists to suggest that an individual's level of stress contributes to the state of many physiological and psychological disorders, The autonomic nervous system, by adjusting parasympathetic and sympathetic activity, is attributed with the control over an individual's level of neural stress. Therefore, it is desired to develop a better and quantitative understanding of the stress! autonomic system mechanism.

Previous work has been done to gain a partial understanding of such activity. The primary objective for this study is to complement and advance the previous work by determining whether there is other physiological data which could reveal ...


Quantitative Estimation Of Heparin Content On Biological Pericadium Tissue Using In Vitro Anti-Factor Xa Assay, Jean-Claude Simeon May 1998

Quantitative Estimation Of Heparin Content On Biological Pericadium Tissue Using In Vitro Anti-Factor Xa Assay, Jean-Claude Simeon

Theses

Shelhigh Inc. (Millburn, NJ) has developed a new heparin binding technique to biological tissues. The technique seems to bind heparin to tissues in a more permanent fashion. Shelhigh's heparinized biological tissues are intended for use in long term implants. This investigation was undertaken to assess whether heparin leaching is prevalent when tissues are quarantine for long shelflife at room temperature, whether tissues maintained thromboresistance properties when in contact with plasma and to estimate heparin content of the tissues.

The study used anti-factor Xa assaying methods: clotting time and chromogenic factor Xa sensitive substrate in order to fulfill the aforementioned ...


Mathematical Model Of Human Sit-To-Stand And Stand-To-Sit Motion Analysis, Jayeshkumar Gandhi May 1998

Mathematical Model Of Human Sit-To-Stand And Stand-To-Sit Motion Analysis, Jayeshkumar Gandhi

Theses

In designing a device for an amputee, it is important to find those underlying principles which determine the normal human sit-to-stand task. For this purpose we have developed a mathematical model of human sit-to-stand movement, which it is possible to predict the minimum mechanical energy consumption to move from the sit-to-stand position.

To the best of author's knowledge, this thesis represents the first time that the periodic motion of stand-to-sit and sit-to-stand movements have been mathematically modeled by a simple mechanical system. A complex model, such as the one used by Seireg and Arvikar (1973) [1] that contained 31 ...


Development Of A Coupled Model Of The Cardiorespiratory And Thermoregulatory Systems , Dawn Denise Downey Jan 1998

Development Of A Coupled Model Of The Cardiorespiratory And Thermoregulatory Systems , Dawn Denise Downey

Retrospective Theses and Dissertations

A model of the human body which integrates the variables involved in temperature regulation and blood gas transport within the cardiovascular and respiratory systems is presented in this dissertation. It expands upon previous work developed by the author to model the competition between skin and muscles when both require increased blood flows during exercise and/or heat stress. First, a detailed study of the control relations used to predict skin blood flow was undertaken. Four other control relations employed in the model were also examined and modified as indicated by empirical results found in literature;Several important cases were then ...


Development Of A Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns For Controlled Regeneration , Yueh-Sheng Chen Jan 1998

Development Of A Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns For Controlled Regeneration , Yueh-Sheng Chen

Retrospective Theses and Dissertations

Silicone rubber multiple-lumen nerve cuffs were used to compare the effectiveness of two varieties of nerve growth stimulants (collagen and a mixture of collagen, fibronectin, and laminin) at the same time for regenerating cables across the same gap. The right sciatic nerve was transected in adult Sprague-Dawley rats. The proximal and distal stumps were inserted each into an end of the single lumen portion of a multiple-lumen cuff in which different chemical fillings were used in 6 tubes of the multiple lumen portion of the cuff. The filling pattern alternated with collagen gel or with a gel mixture of collagen ...


The Effects Of Physiological Levels Of Intermittent Pressure On The Development Of Articular Cartilage In Vitro , Scott Edward Carver Jan 1998

The Effects Of Physiological Levels Of Intermittent Pressure On The Development Of Articular Cartilage In Vitro , Scott Edward Carver

Retrospective Theses and Dissertations

A semi-continuous perfusion system has been designed and constructed to deliver physiological levels of hydrostatic pressure to regenerating cell/polymer constructs of articular cartilage over the long term (weeks to months). Prior to being transferred to the pressurized system, equine articular chondrocytes were dynamically seeded onto nonwoven meshes of polyglycolic acid which provide the cells with a three-dimensional growth environment similar to that found in vivo. When applied in an intermittent manner, physiological pressurization at 500 psi was found to stimulate articular chondrocytes to produce regenerated constructs with greater concentrations of sulfated glycosaminoglycan compared to control (unpressurized) constructs, while the ...


Gamma-Ray Imaging Detector For Small Animal Research, Andrew Gerard Weisenberger Jan 1998

Gamma-Ray Imaging Detector For Small Animal Research, Andrew Gerard Weisenberger

Dissertations, Theses, and Masters Projects

A novel radiation imaging technology for in vivo molecular imaging in small mammals is described. The goal of this project is to develop a new type of imaging detector system suitable for real-time in vivo probe imaging studies in small animals. This technology takes advantage of the gamma-ray and x-ray emission properties of the radioisotope iodine 125 (125I) which is employed as the label for molecular probes. The radioisotope 125I is a gamma-ray emitting radioisotope that can be commercially obtained already attached to biomedically interesting molecules to be used as tracers for biomedical and molecular biology research.;The isotope 125I ...