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Full-Text Articles in Biomedical Engineering and Bioengineering
The Role Of Bone Sialoprotein In Periodontal Tissue Development And Bone Repair, Yohannes Soenjaya
The Role Of Bone Sialoprotein In Periodontal Tissue Development And Bone Repair, Yohannes Soenjaya
Electronic Thesis and Dissertation Repository
Bone development and repair involve complex processes that include interaction between cells and their surrounding matrix. In the body, bone sialoprotein (BSP) expression is up-regulated at the onset of mineralization. BSP is a multifunctional acidic phosphoprotein with collagen-binding, hydroxyapatite nucleating, and integrin recognition (RGD sequence, which is important for cell-attachment and signaling) regions. Mice lacking BSP expression (Bsp-/-), exhibit a bone phenotype with reductions in bone mineral density, bone length, osteoclast activation, and impaired bone healing. This thesis examined the role of BSP in tooth development and also its potential use as a therapeutic reagent for bone …
Engineering Periodontal Tissue Regeneration With The Use Of A Novel Periostin Electrospun Scaffold, Kendal I. Creber
Engineering Periodontal Tissue Regeneration With The Use Of A Novel Periostin Electrospun Scaffold, Kendal I. Creber
Electronic Thesis and Dissertation Repository
Clinical therapies for the treatment of periodontitis are unable to reproducibly stimulate regeneration of the periodontium. We assessed the use of a novel electrospun type I collagen scaffold containing recombinant periostin to stimulate regeneration of the periodontal ligament (PDL) and bone. Human PDL cells demonstrated the ability to form a mineralized matrix in vitro and reduced osteogenic potential with increased donor age. In vitro analysis indicated scaffolds were biocompatible, however, periostin did not significantly influence adhesion or growth. In the healing of fenestration defects in rats, type I collagen scaffolds (with and without periostin) initially delayed cell infiltration and increased …