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Full-Text Articles in Biomedical Engineering and Bioengineering
Prostate Tumor Volume Measurement On Digital Histopathology And Magnetic Resonance Imaging, Mehrnoush Salarian
Prostate Tumor Volume Measurement On Digital Histopathology And Magnetic Resonance Imaging, Mehrnoush Salarian
Electronic Thesis and Dissertation Repository
An accurate assessment of prostate tumour burden supports appropriate treatment selection, ranging from active surveillance through focal therapy, to radical whole-prostate therapies. For selected patients, knowledge of the three-dimensional locations and sizes of prostate tumours on pre-procedural imaging supports planning of effective focal therapies that preferentially target tumours, while sparing surrounding healthy tissue. In the post-prostatectomy context, pathologic measurement of tumour burden in the surgical specimen may be an independent prognostic factor determining the need for potentially life-saving adjuvant therapy. An accurate and repeatable method for tumour volume assessment based on histology sections taken from the surgical specimen would be …
3d Fusion Of Histology To Multi-Parametric Mri For Prostate Cancer Imaging Evaluation And Lesion-Targeted Treatment Planning, Eli Gibson
Electronic Thesis and Dissertation Repository
Multi-parametric magnetic resonance imaging (mpMRI) of localized prostate cancer has the potential to support detection, staging and localization of tumors, as well as selection, delivery and monitoring of treatments. Delineating prostate cancer tumors on imaging could potentially further support the clinical workflow by enabling precise monitoring of tumor burden in active-surveillance patients, optimized targeting of image-guided biopsies, and targeted delivery of treatments to decrease morbidity and improve outcomes. Evaluating the performance of mpMRI for prostate cancer imaging and delineation ideally includes comparison to an accurately registered reference standard, such as prostatectomy histology, for the locations of tumor boundaries on mpMRI. …