Biomedical Engineering and Bioengineering Commons^™

Simpliscope: A Novel Device For In-Office Laryngeal Biopsies, Margaret Schuermann, Aris Rassias, Noah Barney, Alexandra Lipsky

Honors Theses

In order to screen for laryngeal cancer, a biopsy is performed to take a tissue sample from that area of interest. Due to the risk involved these procedures take place in the operating room where a larger sample can be obtained, but delays in scheduling operating room procedures put patients at a greater risk as their diagnosis can be delayed. We want to create a device that is able to move these delayed operating room procedures in-of ice where the physician can treat the patient quickly and safely. Our goal is to increase the accuracy of in-office laryngeal biopsies while …

Orthopedic Anti-Plunging With External Cooling Drill System, David Bates, Nick Muro, Olivia Bresett, Laura Wind

Honors Theses

There are 22 million orthopedic surgeries performed globally each year and this number is expected to increase by approximately 6 million by 2022. Within many of these operations, surgeons are required to utilize orthopedic drills to properly insert various implants to facilitate healing within the body. Unfortunately, many of these procedures have complications that result in thermal osteonecrosis or bone plunging. These complications cause the death of bone cells due to heat and the loosening of an implant from drilling through the entirety of the bone, respectively. To help prevent these detrimental issues, we seek to redesign the orthopedic drilling …

Device For Affixation Of Rear-Facing Child Restraint System To Ambulance Cot For Non-Emergent Transport, Troy Kohler, Kendall Rogoff, Matthew Miller, Lily Buchanan

Honors Theses

During motor vehicle travel it is a near-universal practice to transport infants in a rear-facing car seat, formally known as a child restraint system (CRS). Car seats are subject to heavy regulations, extensive testing, and are safe, secure, and familiar environments for infants. The use of a CRS reduces fatalities associated with motor vehicle collisions by up to 71%. Current devices on the market for pre-hospital infant transport are harness-based and do not utilize these car seats. Aversion to use of these harnesses occurs for a variety of reasons. The device becomes visually unattractive after remaining in storage for long …

K-Wire Differentiation, Oluwadamilola Oluwadara, Lillian Maresco, Eunjung Lee, Michelle De Leon

Honors Theses

Kirschner Pins, known as K-wires, are smooth sharp stainless steel pins used in the field of orthopedics to stabilize bone fracture fragments in their correct position until they have fully healed. K-wires are most commonly used for comminuted metaphyseal fractures of the long bones, and fractures of smaller bones such as the phalanges. The wires are inserted into bone via a drill and the ends of the wire are bent and left outside of the body for easy removal once the bone has healed. The surgeon uses x-ray images to guide K-wire insertion, ensure proper internal alignment, and determine if …

Device For Affixation Of Rear-Facing Child Restraint System To Ambulance Cot For Non-Emergent Transport, Matthew Miller, Kendall Rogoff, Troy Kohler, Lily Buchanan

Honors Theses

During motor vehicle travel it is a near-universal practice to transport infants in a rear-facing car seat, formally known as a child restraint system (CRS). Car seats are subject to heavy regulations, extensive testing, and are safe, secure, and familiar environments for infants. The use of a CRS reduces fatalities associated with motor vehicle collisions by up to 71%. Current devices on the market for pre-hospital infant transport are harness-based and do not utilize these car seats. Aversion to use of these harnesses occurs for a variety of reasons. The device becomes visually unattractive after remaining in storage for long …

Pediatric Pulse Oximeter For Low Resource Countries, Celina Francis, Alexandra Kucinski, Lara Atalay, Saniyah Dar, Fatima Shaat

Honors Theses

In Sub-Saharan Africa, 1 in 5 children are admitted to the hospital due to below average levels of oxygen in the blood caused by respiratory illnesses such as pneumonia. Other acute lower respiratory infections account for 1.4 million deaths annually in low resource areas. Pulse oximetry is commonly used to measure oxygen saturation levels, specifically for those with compromised respiratory conditions, to make sure that enough oxygen is being transported to the extremities. Low resource countries face many challenges to access pulse oximeters, mainly due to cost and durability of the device. This lack of oximeters decreases the ability to …

A Revolutionary Approach To Transsphenoidal Surgery: The Pedg, Paidamoyo Ewing, Lavonia Duncan, Giselle Perkowski, Erendira Garcia Pallares

Honors Theses

Approximately 1500 pituitary tumors diagnosed each year are tough textured microadenomas found mainly in patients aging from 55-80 [1]. Tough textured tumors in the pituitary gland can cause hormonal imbalances and vision changes. For our Capstone Project, we focused on designing an endonasal device, the Pituitary Endonasal Deep Grasper (PEDG), that improves the efficiency of tough textured pituitary tumor removal by improving upon various mechanisms in Transsphenoidal Surgery including rotation, tip grasping, suction, and handle control. Our device contains a comfortable handle that allows for better control and precision during the procedure. We designed a grasping mechanism that is strong …

Redesigned Endoscopic Bite Block For Geriatric Patients, Kayla Fisher, Katherine Gregory, Owen Corey

Honors Theses

Esophagogastroduodenoscopy (EGD) is an examination of the interior of the esophagus, stomach, and beginning of the small intestine. Upper gastrointestinal (GI) endoscopies are used to diagnose ulcers, cancers, and gastrointestinal tract diseases, as well as to collect biopsy samples. In 2008, over 55 million procedures were performed with GI endoscopic devices [1]. In order to keep the mouth propped open during this procedure, a bite block is used. This bite block ensures that the patient will not bite down on the endoscope during the procedure. Geriatric patients are more likely to have poor dental health due to medications they take, …

Sol Retractor: Rapidly Deployable Film-Based C-Section Retractor, Casey Lee, Silas Cleveland, Jose Dolores Valdivieso, Joseph Perks

Honors Theses

Cesarean Sections (C-sections), a surgery conducted for baby delivery, can be divided into four distinct categories; Category 1 and 2 are considered emergency c-sections, and Category 3 and 4 are scheduled c-sections [2]. A comparative study from 2016 analyzed the difference of need for postoperative treatment between the Collins or the Alexis O retractor ( n = 100). The Alexis O C-Section retractor resulted in 19% of women requiring postoperative treatment, including medication, monitoring, and an extended stay at the hospital. The Collins resulted in 43% of the patients requiring postoperative treatment (p = 0.001) [5]. In emergency C-sections, surgical …

Breathe Easy: A More Efficient Way To Avoid Tracheostomy Airway Blockages, Katelynn Russ, Kathleen Swanson, Olivia Zimmerman

Honors Theses

Over 100,000 people receive tracheostomies each year in the United States when mechanical ventilation is needed for longer than 48 hours, a patient has a chronically obstructed airway, or the patient is unable to protect their airway from aspiration. A tracheostomy is inserted into a patient’s trachea in order to modify their airway through a tracheotomy procedure. A tracheostomy tube alters the natural lining of an airway which normally has a 5-50 μm thick layer of mucus. An airway with a tracheostomy tube produces more mucus than the average airway of a healthy person, and it also limits the patient’s …

A Novel Device To Remove Kidney Stone Fragments From The Ureter, Madeline Feinberg, Christina Pavlovsky, John Kasel

Honors Theses

Every year kidney stones affect 654,000 Americans and 25% of these cases require a ureteroscopy which is performed on patients with kidney stones greater than 4 mm in the ureter. A holmium laser is used to rupture the kidney stone resulting in fragmentation of the stone. If not removed, these residual fragments can cause pain and may require a secondary procedure to remove them. The most common method for removing stone fragments is inserting a basket device through a port on the ureteroscope, encapsulating individual stone fragments, and manually removing the device. This device requires multiple insertions to remove the …

Breathe Easy: A More Efficient Way To Avoid Tracheostomy Airway Blockages, Kathleen Swanson, Katelynn Russ, Olivia Zimmerman

Honors Theses

Over 100,000 people receive tracheostomies each year in the United States when mechanical ventilation is needed for longer than 48 hours, a patient has a chronically obstructed airway, or the patient is unable to protect their airway from aspiration. A tracheostomy is inserted into a patient’s trachea in order to modify their airway through a tracheotomy procedure. A tracheostomy tube alters the natural lining of an airway which normally has a 5-50 μm thick layer of mucus. An airway with a tracheostomy tube produces more mucus than the average airway of a healthy person, and it also limits the patient’s …

Breathe Easy: A More Efficient Way To Avoid Tracheostomy Airway Blockages, Olivia Zimmerman, Kathleen Swanson, Katelynn Russ

Honors Theses

ZIMMERMAN, OLIVIA Breathe Easy: A More Efficient Way to Avoid Tracheostomy Airway Blockages

Department of Biomedical Engineering, June 2020.

ADVISOR: Professor Cotter and Professor Khetan

An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Megan Morrissey, Jillian Yeager, Julia Beekman

Honors Theses

Hospital acquired pressure ulcers (HAPUs), also called bedsores, are damage to the skin and/or underlying tissue caused by prolonged pressure on the bony areas of the body, with around 20% of pressure ulcers occurring in the heel region. Currently, the most common practice for HAPU prevention is arbitrary manual repositioning of patients by nurses every 1-2 hours. The goal of our project was to address HAPUs in the heel region of low mobility patients through an ulceration risk sensing system. Our team has created a wearable ulceration risk assessment system that combines individual patient risk data with real time pressure …

An Improved Method For Hospital Acquired Pressure Ulcer (Hapu) Prevention, Julia Beekman, Jillian Yeager, Megan Morrissey

Honors Theses

Hospital acquired pressure ulcers (HAPUs), also called bedsores, are damage to the skin and/or underlying tissue caused by prolonged pressure on the bony areas of the body, with around 20% of pressure ulcers occurring in the heel region. Currently, the most common practice for HAPU prevention is arbitrary manual repositioning of patients by nurses every 1-2 hours. The goal of our project was to address HAPUs in the heel region of low mobility patients through an ulceration risk sensing system. Our team has created a wearable ulceration risk assessment system that combines individual patient risk data with real time pressure …

Applying An Innovative Idea To Kidney Stone Removal, Jack Beaty

Honors Theses

Renal lithiasis, commonly referred to as “kidney stones” is a condition in which the urine composition crystallizes and cannot pass through the ureter, causing pain and discomfort. Renal lithiasis can be caused by diet, infection, reduced water retention, or hereditary disorders; each of which results in a distinct stone composition [1]. Stone compositions can vary between calcium oxalate, struvite, uric acid, and cystine[2]. Each stone type, however, provides the same pain to the patient and the same potential risk of blocking the urinary system.

Kidney stone symptoms may include but are not limited to: pain in the lower back, the …

The Theia Soteria: Alternative Design For Safer Initial Entry During Laparoscopic Procedures, Kayla Dubois, Patrick Ryan, Madelyn Joanis

Honors Theses

Laparoscopic procedures account for 15 million surgeries worldwide [1], with the initial entry into the peritoneal cavity accounting for 33-50% of all major laparoscopic complications [7]. This initial entry is the most dangerous as surgeons must enter the cavity using a sharp object with no visibility and space between the outer surface of the cavity and internal tissues. During the initial entry into the peritoneal cavity, the patients undergoing laparoscopic procedures are at a high risk for damage to internal organs and vasculature, necessitating the development of a device to protect these internal tissues and increase patient safety.

Designing A Low-Cost Ultrasound Pulser, Andrea Huey

Honors Theses

Ultrasound imaging allows for those studying living beings to see inside a subject without causing it harm. This allows for real-time images to be taken, leading to ease of observational research. However, while this technology is beneficial to those who utilize it, the devices used to create and receive ultrasound pulses can be incredibly complex, allowing for precise adjustment of the output signal and various other functions, and therefore expensive. The focus of this senior project is the design of a low-cost pulser for use with an ultrasound transducer. While it does not have all the high-level functions of the …

Ar Blockers, Emma Merlino, Charles Nelson, Brendan Laing

Honors Theses

Access Recirculation (AR) severely decreases the efficiency of dialysis while having the potential to lead to a variety of complications (Fig. 3). If recirculation occurs during treatment, the patient may be at risk of developing stenosis (narrowing of blood vessels), leading to thrombosis (the local coagulation/clotting of blood) [4]. The most influential cause of recirculation results from the misplacement of the arterial and venous needles that will significantly harm the patient, wasting both money and resources. It is clear that the medical community has focused their energy on developing a proactive approach to monitoring AR, instead of preventing it. Creating …

Prevention Of Access Recirculation During Hemodialysis Treatment, Brendan Laing, Emma Merlino, Charles Nelson

Honors Theses

Approximately 660,000 Americans are being treated for kidney failure or end stage renal disease annually. Access recirculation can happen to any patient, varying from treatment to treatment, as it is a problem with the current technology of two butterfly needles used during a dialysis procedure and not with the patient. Access Recirculation severely decreases the efficiency of dialysis while having the potential to lead to a variety of complications.There is a clear need for a device that can be implemented during hemodialysis treatments to reduce the percentage of recirculated blood, thusly reducing the occurrence of treatment for an individual and …

Cuffed Pediatric Endotracheal Tubes, Jennifer Nutter, Emmanuela Oppong, Colleen Pouliot

Honors Theses

Endotracheal tubes (ET) are used to provide patients with an adequate airway when they are unable to breathe on their own. ET tubes can be used in emergency situations, surgical procedures, and on-floor intubations. The two main types of ET tubes are cuffed and uncuffed. Due to the fragile structure of a child's throat, uncuffed tubes are primarily used in pediatric patients. Uncuffed tubes can slip out of place resulting in air leakage and improper oxygenation. In contrast, cuffed ET tubes provide a proper seal to the airway and prevent against aspiration. The following work proposes an improved design for …

Design Of A Double-Dose Epinephrine Auto-Injector Using 3d-Printing, Timothy Calvin Sheehan

Honors Theses

This project involved the design and prototyping of an epinephrine auto-injector capable of administering two separate doses. Epinephrine auto-injectors are used in the treatment of patients undergoing anaphylaxis, an allergic reaction causing the restriction of airways and a drop in blood pressure. The timely administration of epinephrine counteracts these symptoms and can be lifesaving. Currently the only devices available to consumers administer one unit dose of epinephrine and are then no longer usable. In 30% of cases where patients undergo these symptoms a second dose of epinephrine is required. My design was based partially off the concept behind currently available …

Studying The Material Properties Of The Embryonic Chicken Heart, Kyra Burnett

Honors Theses

Congenital heart disease is the number one cause of birth defects in the United States, affecting approximately 40,000 newborns each year. Research has shown that serious structural defects of the heart can occur due to abnormal looping. Looping refers to the positional and morphological changes of the early embryo heart and is divided into different phases. Although progress has been made in identifying the genetic processes behind heart looping, the forces involved with the developmental process are still not fully understood. In this research, the chicken embryo heart was used as the experimental model and certain material properties were characterized. …

History Of Concussion Research In American Football, Timothy Hersey

Honors Theses

Concussions have been the topic of discussion in the news and media in recent years for their profound impact on today’s sport industry. Athletes have become bigger, faster, and stronger then in the past, increasing the chance of injury. This can been seen in all sports. Contact sports specifically have seen a rise in mild traumatic brain injuries (MTBIs) over the years. Extensive research has been done to determine the causes of concussion, the short and long term effects of brain injury, and better ways to reduce the risk in sports. Concussion research in athletics has mainly focused on American …

Coupling Of Audio Signals Into Afm Images, Matthew Manning

Honors Theses

It is well known that Atomic Force Microscopy imaging is capable of yielding high resolution results with of surfaces at the nanoscale. However, despite the device capabilities and vast applications, AFM microscopy is possibly the most prone to the creation of image artifacts. AFM imaging can easily, and is often, corrupted by various external forces. The most obvious and measurable form of external interference is of course the presence of ambient noise. Most AFM manufactures attempt to counter the effects of such noise on the imaging process through use of noise-proof or noise-resistant shields that cover the microscope aperture. Without …

Measuring The Strain Field Gradients On The Surface Of A Model Human Skull While Axially Loaded To Simulate Head-Loading, Matthew Graveley

Honors Theses

Head-loading is a means of transporting heavy loads accross rough, rural terrains practiced by many peoples in Third World countries. Years of practicing head-loading is said to result in increase spinal bone density and permantly grooved skulls. The most infamous people who practice head-loading are the porters of Nepal, who carry loads by means of a head sling straped across their foreheads, and South African women, who carry loads directly on their heads. To simulate and measure the instantaneous micro deformations occurring on the surface of the skull due to head-loading, a test procedure has been developed using a plastic …

Mechanical Characterization Of An External Fixator For Use In A Mouse Model, Thomas Albano

Honors Theses

Understanding the process of bone healing has become a fundamental part of medical research due to the approximately one million fractures which occur annually in the United States. The current methods of fracture fixation which use intramedullary rods, external fixators, and fracture plates are effective but not ideal. These fracture fixation methods can lead to mal-union or non-union due to improper callus formation stemming from inadequate fixation and support. When mal-union and non-union occur, the structural integrity of the bone becomes greatly sacrificed and the patient is left to deal with continual pain. Previous studies have suggested that the mechanical …

Traumatic Vs. Pathological Achilles Tendon Ruptures: A Look Into The Importance Of The Collagen Matrix And The Preferred Method Of Repair, Kathleen M. Mclean

Honors Theses

The Achilles tendon is the largest, strongest, and thickest tendon in the human body. While it may be the strongest, the Achilles tendon is also among one of the most frequently ruptured. These lower limb injuries arise as a result of athletically induced trauma or pathologically and steroidal induced trauma. While the manner in which athletic ruptures occurs can be determined on a case to case basis through the use of clinical examination, ultrasonography, and magnetic resonance imaging (MRI), the method in which the injury should be treated remains controversial. The two main methods of repair include a conservative approach …

Design And Validation Of An External Fixator For Use In In Vivo Fracture Studies, Marc S. Nash

Honors Theses

This thesis explores how a new external fixator effects the healing process in the fracture site of a mouse tibia. Studies have shown that the amount of time it takes a fracture to heal can vary based on the type of fixator used. An external fixator was designed using SolidWorks and fabricated by Medical Micro Machining (Colfax, Washington). Rubber disks where created from a mold and inserted in the bottom piece of each fixator. Using a dental drill and a variety of clamps, the fixator was attached to an already removed tibia. A Dremel saw was used to create a …