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Electrochemical Detection Of Reactive Oxygen Species Via A Platinum Microelectrode Array, Victor M. Carriere Jr.
Electrochemical Detection Of Reactive Oxygen Species Via A Platinum Microelectrode Array, Victor M. Carriere Jr.
Master's Theses
Oxidative stress, an excess of endogenous or exogenous reactive oxygen species (ROS) in the body, is closely aligned with inflammatory responses. ROS such as hydrogen peroxide, superoxide, and radical hydroxyl ion serve essential functions in fighting infection, but chronic elevation of these species irreversibly damages cellular components. Given the central role of inflammation in a variety of diseases, including Alzheimer’s Disease, atherosclerosis, and rheumatoid arthritis, a low-cost, extracellular, non-invasive assay of ROS is needed.
This work reports the use of a platinum microelectrode array (Pt MEA)-based ceramic probe to detect time- and concentration-dependent variations in hydrogen peroxide (H2O2) production by …
Detecting And Screening Of The Prostate Cancer By Using An Optical Nanoporous Thin-Film Sensor, Salah Eldeen Mofleh Alzghoul
Detecting And Screening Of The Prostate Cancer By Using An Optical Nanoporous Thin-Film Sensor, Salah Eldeen Mofleh Alzghoul
Doctoral Dissertations
Prostate cancer (PC) affects elderly men more than young men. The currently used cancer biomarker, prostate-specific antigen (PSA), highly overestimates PC population. Men with high PSA levels often have to go through unnecessary, but physically painful, and expensive prosesses, such as prostate biopsies. Finding a prostate cancer marker that is produced selectively by cancer, but not by normal prostate cells will increase the reliability of PC test. In 2006, our collaborator (Dr. Girish Shah) discovered a novel protein, referred as neuroendocrine marker (NEM), secreted only by malignant prostate cells and released in blood circulation.
To examine whether the combined NEM-PSA …