Biomedical Engineering and Bioengineering Commons^™

Effects Of Hard-To-Soft Segment Ratios On The Synthesis And Physico-Mechanical Properties Of Polyurethane Films, Aaron C. Wilson

Mechanical Engineering Theses

Blood-contacting cardiovascular stents often induce a secondary clotting event due to unrestricted enzymatic activities. The use of hemocompatible polyurethane coatings on these implantable devices is one of the most promising methods to reduce device rejection. In this study, four commercial polyurethane films of various thicknesses and compositions were evaluated for their anticoagulation properties. Results suggested that these films exhibited excellent thermal and physico-mechanical properties while capable of increasing contact time with blood plasma by over a thousand-fold as compared to a control surface. Due to the unknown structure and composition of these commercial films, polyurethane samples were synthesized from toluene …