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Full-Text Articles in Biomedical Engineering and Bioengineering
Measuring The Effect Of Airway Pressure On Pulmonary Arterial Diameter In The Intact Rat Lung, Robert C. Molthen, Steven Thomas Haworth, Amy Heinrich, Christopher A. Dawson
Measuring The Effect Of Airway Pressure On Pulmonary Arterial Diameter In The Intact Rat Lung, Robert C. Molthen, Steven Thomas Haworth, Amy Heinrich, Christopher A. Dawson
Biomedical Engineering Faculty Research and Publications
To study the relationship between transpulomnary [sic] pressure (Ptp), intravascular pressure (Pv), and the pulmonary arterial tree structure, morphometric measurements of pulmonary arterial trees were made in intact lungs from Sprague-Dawley rats. Using cone beam micro-CT and techniques we developed for imaging small animal lungs, volumetric CT data were acquired for Ptp from 0 - 12 mmHg and Pv from 5 - 30 mmHg. The diameter, D (measured range approximately 0.08-2.0 mm), vs. pressure, P, relation can be described by D(P) = D(0)(1+ α P), where α is a distensibility coefficient. Unlike studies performed in larger animals, where changes in …
Spect Imaging Of Pulmonary Blood Flow In A Rat, Christian Wieholt, Robert C. Molthen, Roger H. Johnson, Christopher A. Dawson, Anne V. Clough
Spect Imaging Of Pulmonary Blood Flow In A Rat, Christian Wieholt, Robert C. Molthen, Roger H. Johnson, Christopher A. Dawson, Anne V. Clough
Biomedical Engineering Faculty Research and Publications
Small animal imaging is experiencing rapid development due to its importance in providing high-throughput phenotypic data for functional genomics studies. We have developed a single photon emission computed tomography (SPECT) system to image the pulmonary perfusion distribution in the rat. A standard gamma camera, equipped with a pinhole collimator, was used to acquire SPECT projection images at 40 sec/view of the rat thorax following injection of Tc99m labeled albumin that accumulated in the rat's lungs. A voxel-driven, ordered-subset expectation maximization reconstruction was implemented. Following SPECT imaging, the rat was imaged using micro-CT with Feldkamp conebeam reconstruction. The two reconstructed image …