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Biomedical Engineering and Bioengineering Commons™
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- Aptamer (1)
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- Electrospun Nanofibers (1)
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- MS2 Bacteriophage (1)
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Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Micropatterned Electrospun Nanofibrous Substrates As Scaffolds For Engineered Salivary Glands, David Alexander Soscia
Micropatterned Electrospun Nanofibrous Substrates As Scaffolds For Engineered Salivary Glands, David Alexander Soscia
Legacy Theses & Dissertations (2009 - 2024)
The salivary gland is a complex organ exhibiting a branching, 3-dimensional structure made up of acinar (saliva-producing), and ductal (saliva transporting and modifying) epithelial cells. The high surface area of the gland allows it to efficiently provide the mouth with saliva, maintaining oral cleanliness and comfort. Salivary gland hypofunction, a significant clinical problem often caused by the autoimmune disease Sjögren's syndrome or head and neck radiation for cancer patients, affects millions of Americans and is characterized by a loss of function of salivary gland acinar cells. Chronic xerostomia, or dry mouth, arises as a result of salivary gland hypofunction and …
Bioengineering Embryonic Microenvironment For Exploring Stem Cell-Breast Cancer Cell Interactions, Nurazhani Abdul Raof
Bioengineering Embryonic Microenvironment For Exploring Stem Cell-Breast Cancer Cell Interactions, Nurazhani Abdul Raof
Legacy Theses & Dissertations (2009 - 2024)
Embryonic stem (ES) cells and breast cancer cells share similar signaling pathways that allow cells to proliferate and differentiate. However, signaling molecules in cancer cells are misexpressed. Cell microenvironments that consist of many factors such as soluble factors, extracellular matrices, and neighboring cells, play a pivotal role in determining cellular fate. The exposure of ES cell microenvironments to cancer cells may address the missing components in the tumor microenvironment, which could inhibit tumorigenesis or reprogram cancer cells into a less invasive phenotype. In this thesis, in vitro ES cell microenvironments have been engineered three-dimensionally via alginate hydrogel encapsulation and patterned …
Virus Capsids As Nanoscale Delivery Vessels Of Photoactive Compounds For Site-Specific Photodynamic Therapy, Brian Alexander Cohen
Virus Capsids As Nanoscale Delivery Vessels Of Photoactive Compounds For Site-Specific Photodynamic Therapy, Brian Alexander Cohen
Legacy Theses & Dissertations (2009 - 2024)
The research presented in this work details the use of a viral capsid as an addressable delivery vessel of photoactive compounds for use in photodynamic therapy. Photodynamic therapy is a treatment that involves the interaction of light with a photosensitizing molecule to create singlet oxygen, a reactive oxygen species. Overproduction of singlet oxygen in cells can cause oxidative damage leading to cytotoxicity and eventually cell death. Challenges with the current generation of FDA-approved photosensitizers for photodynamic therapy primarily stem from their lack of tissue specificity. This work describes the packaging of photoactive cationic porphyrins inside the MS2 bacteriophage capsid, followed …