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Full-Text Articles in Biomedical Engineering and Bioengineering
Study Of Porosity Of Gelatin-Alginate Hydrogels To Model Brain Matter For Studying Traumatic Brain Injuries, Apolline Vincent
Study Of Porosity Of Gelatin-Alginate Hydrogels To Model Brain Matter For Studying Traumatic Brain Injuries, Apolline Vincent
Honors Scholar Theses
Traumatic brain injuries (TBIs) affect brain tissue and neuronal signaling, leading to many side effects including death. Research on TBIs is limited by the lack of accurate brain matter models to study the physiological and cellular reaction. Alginate-gelatin hydrogels have been designed and modified to mimic the mechanical properties of the brain to act as an accurate in vitro model. This Honors thesis aims to verify the porous microstructure of gelatin-alginate hydrogels through Scanning Electron Microscopy (SEM) to understand how gelatin and alginate affect the microstructure. I measured the pore sizes of each hydrogel using ImageJ, compared the average pore …
Mechanical Analysis Of In Vitro Tbi Models, Dana Hamed
Mechanical Analysis Of In Vitro Tbi Models, Dana Hamed
Honors Scholar Theses
This work details the damage done to cells when mechanically hit. The goal was to mechanically analyze in vitro traumatic brain injury (TBI) models. Parts were designed in SolidWorks to create the machine that is used to induce this damage on the cells. A force applicator that uses a 3D-printed micro-hammer to apply force on the brain cells that are being tested was created. Mechanical trauma experimentation was performed with the force applicator, while a high-speed camera recorded the damage, in order to analyze TBI models. Displacement along the scaffold can be tracked from multiple video frames. With these results, …