Biomedical Engineering and Bioengineering Commons^™

Light Sheet Microscopy Incubation Design And Control Scheme, Venkatanathan Kidambi

Honors Scholar Theses

The focus of the following paper is the development of a light sheet or selective plane illumination microscopy (LSM / SPIM) platform to support long duration three dimensional imaging of various cells and tissues. This paper describes the complete design and fabrication process behind the prototype, including a definition of light sheet microscopy and its differences from confocal microscopy, as well as existing open source selective plane microscopy literature and designs. The complete engineering design process as applied to the microscope design is described in detail. Specifically, this paper will focus on the development of an incubation chamber for light …

Seeing Eye To Eye: A Machine Learning Approach To Automated Saccade Analysis, Maigh Attre

Honors Scholar Theses

Abnormal ocular motility is a common manifestation of many underlying pathologies particularly those that are neurological. Dynamics of saccades, when the eye rapidly changes its point of fixation, have been characterized for many neurological disorders including concussions, traumatic brain injuries (TBI), and Parkinson’s disease. However, widespread saccade analysis for diagnostic and research purposes requires the recognition of certain eye movement parameters. Key information such as velocity and duration must be determined from data based on a wide set of patients’ characteristics that may range in eye shapes and iris, hair and skin pigmentation [36]. Previous work on saccade analysis has …

Near Infrared Imaging System, Barbara Adu-Baffour

Honors Scholar Theses

This senior project is to design and fabricate a near infrared imaging system using laser diodes for imaging biological tissues. The device will have three major sections comprising the signal source, detection and data analysis sections.

In the source signal section, a circuit would be designed and built which will contain two laser diodes with different wavelengths (780nm and 830nm). Each of the two laser diodes will modulated at different frequencies to enable a spatial coding system. The detection section of the device will have an optical detector channel which will be designed to detect signals from all the laser …