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Full-Text Articles in Biomedical Engineering and Bioengineering

Solution Of Population Balance Equations In Applications With Fine Particles: Mathematical Modeling And Numerical Schemes, Tan Trung Nguyen, Frédérique Laurent, Rodney O. Fox, Marc Massot Nov 2016

Solution Of Population Balance Equations In Applications With Fine Particles: Mathematical Modeling And Numerical Schemes, Tan Trung Nguyen, Frédérique Laurent, Rodney O. Fox, Marc Massot

Chemical and Biological Engineering Publications

The accurate description and robust simulation, at relatively low cost, of global quantities (e.g. number density or volume fraction) as well as the size distribution of a population of fine particles in a carrier fluid is still a major challenge for many applications. For this purpose, two types of methods are investigated for solving the population balance equation with aggregation, continuous particle size change (growth and size reduction), and nucleation: the extended quadrature method of moments (EQMOM) based on the work of Yuan et al.[52]and a hybrid method (TSM) between the sectional and moment methods, considering two ...


Recovery And Utilization Of Lignin Monomers As Part Of The Biorefinery Approach, Kirsten M. Davis, Marjorie Rover, Robert C. Brown, Xianglan Bai, Zhiyou Wen, Laura R. Jarboe Oct 2016

Recovery And Utilization Of Lignin Monomers As Part Of The Biorefinery Approach, Kirsten M. Davis, Marjorie Rover, Robert C. Brown, Xianglan Bai, Zhiyou Wen, Laura R. Jarboe

Chemical and Biological Engineering Publications

Lignin is a substantial component of lignocellulosic biomass but is under-utilized relative to the cellulose and hemicellulose components. Historically, lignin has been burned as a source of process heat, but this heat is usually in excess of the process energy demands. Current models indicate that development of an economically competitive biorefinery system requires adding value to lignin beyond process heat. This addition of value, also known as lignin valorization, requires economically viable processes for separating the lignin from the other biomass components, depolymerizing the lignin into monomeric subunits, and then upgrading these monomers to a value-added product. The fact that ...


Strongly Coupled Fluid-Particle Flows In Vertical Channels. I. Reynolds-Averaged Two-Phase Turbulence Statistics, Jesse Capecelatro, Olivier Desjardins, Rodney O. Fox Mar 2016

Strongly Coupled Fluid-Particle Flows In Vertical Channels. I. Reynolds-Averaged Two-Phase Turbulence Statistics, Jesse Capecelatro, Olivier Desjardins, Rodney O. Fox

Chemical and Biological Engineering Publications

Simulations of strongly coupled (i.e., high-mass-loading) fluid-particle flows in vertical channels are performed with the purpose of understanding the fundamental physics of wall-bounded multiphase turbulence. The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions are presented, and the unclosed terms that are retained in the context of fully developed channel flow are evaluated in an Eulerian–Lagrangian (EL) framework for the first time. A key distinction between the RA formulation presented in the current work and previous derivations of multiphase turbulence models is the partitioning of the particle velocity fluctuations into spatially correlated and uncorrelated components, used to define the ...


Strongly Coupled Fluid-Particle Flows In Vertical Channels. Ii. Turbulence Modeling, Jesse Capecelatro, Olivier Desjardins, Rodney O. Fox Jan 2016

Strongly Coupled Fluid-Particle Flows In Vertical Channels. Ii. Turbulence Modeling, Jesse Capecelatro, Olivier Desjardins, Rodney O. Fox

Chemical and Biological Engineering Publications

In Part I, simulations of strongly coupled fluid-particle flow in a vertical channel were performed with the purpose of understanding, in general, the fundamental physics of wall-bounded multiphase turbulence and, in particular, the roles of the spatially correlated and uncorrelated components of the particle velocity.The exact Reynolds-averaged (RA) equations for high-mass-loading suspensions were presented, and the unclosed terms that are retained in the context of fully developed channel flow were evaluated in an Eulerian–Lagrangian (EL) framework. Here, data from the EL simulations are used to validate a multiphase Reynolds-stress model (RSM) that predicts the wall-normal distribution of the ...


Accounting For Host Cell Protein Behavior In Anion-Exchange Chromatography, Ryan K. Swanson, Ruo Xu, Daniel S. Nettleton, Charles Glatz Jan 2016

Accounting For Host Cell Protein Behavior In Anion-Exchange Chromatography, Ryan K. Swanson, Ruo Xu, Daniel S. Nettleton, Charles Glatz

Chemical and Biological Engineering Publications

Host cell proteins (HCP) are a problematic set of impurities in downstream processing (DSP) as they behave most similarly to the target protein during separation. Approaching DSP with the knowledge of HCP separation behavior would be beneficial for the production of high purity recombinant biologics. Therefore, this work was aimed at characterizing the separation behavior of complex mixtures of HCP during a commonly used method: anion-exchange chromatography (AEX). An additional goal was to evaluate the performance of a statistical methodology, based on the characterization data, as a tool for predicting protein separation behavior. Aqueous two-phase partitioning followed by two-dimensional electrophoresis ...


High Throughput Studies Of Cell Migration In 3d Microtissues Fabricated By A Droplet Microfluidic Chip, Xiangchen Che, Jacob A. M. Nuhn, Ian C. Schneider, Long Que Jan 2016

High Throughput Studies Of Cell Migration In 3d Microtissues Fabricated By A Droplet Microfluidic Chip, Xiangchen Che, Jacob A. M. Nuhn, Ian C. Schneider, Long Que

Chemical and Biological Engineering Publications

Arrayed three-dimensional (3D) micro-sized tissues with encapsulated cells (microtissues) have been fabricated by a droplet microfluidic chip. The extracellular matrix (ECM) is a polymerized collagen network. One or multiple breast cancer cells were embedded within the microtissues, which were stored in arrayed microchambers on the same chip without ECM droplet shrinkage over 48 h. The migration trajectory of the cells was recorded by optical microscopy. The migration speed was calculated in the range of 3–6 µm/h. Interestingly, cells in devices filled with a continuous collagen network migrated faster than those where only droplets were arrayed in the chambers ...