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Full-Text Articles in Biomedical Engineering and Bioengineering
Design Of A Modular Endothelialized Platform For Vascularized Bone Regeneration, Kevin Barrett Miles
Design Of A Modular Endothelialized Platform For Vascularized Bone Regeneration, Kevin Barrett Miles
Wayne State University Dissertations
The gold standard for bone regeneration requires harvesting a piece of healthy bone from the patient through a painful procedure, but this piece of autologous bone graft contains the bone and endothelial cells required to rapidly regenerate bone in a defect. We have developed a modular bone regeneration platform, composed of mesenchymal stem cells (MSCs) and hydroxyapatite (HAP) microgranules encapsulated in microcapsules, to replace autologous graft harvesting. The microcapsules are composed of a polyelectrolyte membrane formed by the ionic-complex reaction between chondroitin 4-sulfate (C4S) and chitosan. The specific aims of this thesis were to 1) examine the ability of C4S/HAP/chitosan …
Supercritical Carbon Dioxide-Processed Resorbable Polymer Nanocomposites For Bone Graft Substitute Applications, Kevin Baker
Supercritical Carbon Dioxide-Processed Resorbable Polymer Nanocomposites For Bone Graft Substitute Applications, Kevin Baker
Wayne State University Dissertations
Numerous clinical situations necessitate the use of bone graft materials to enhance bone formation. While autologous and allogenic materials are considered the gold standards in the setting of fracture healing and spine fusion, their disadvantages, which include donor site morbidity and finite supply have stimulated research and development of novel bone graft substitute materials. Among the most promising candidate materials are resorbable polymers, composed of lactic and/or glycolic acid. While the characteristics of these materials, such as predictable degradation kinetics and biocompatibility, make them an excellent choice for bone graft substitute applications, they lack mechanical strength when synthesized with the …