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Traumatic Brain Injury Induced Cerebral Blood Flow Changes - A Potential Role For Caffeine, Sharath Chandra Reddy Bandaru
Traumatic Brain Injury Induced Cerebral Blood Flow Changes - A Potential Role For Caffeine, Sharath Chandra Reddy Bandaru
Wayne State University Theses
Traumatic brain injury (TBI) is a global health problem with significant socio-economic costs. Closed head TBIs are one of the major causes of physical disability and cognitive disorder in young adults and a leading cause of death in children.
Alteration in cerebral blood flow due to an impaired autoregulation is one of the most common consequences of TBI. However, studies related to understanding the temporal changes in CBF following TBI in experimental models are limited. The few available studies report acute reduction in CBF following TBI; knowledge related to CBF changes at sub-acute periods extending to 7 days after TBI …