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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
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- Acanthosis Nigricans, Diffuse Reflectance Spectroscopy and Colorimetry, Head and neck squamous cell carcinoma, Neuroblastoma and ganglioneuroma, Prostate cancer, Raman Spectroscopy (1)
- Acoustic emission, Cardiovascular physical model, CFD simulation, Fluid flow regime, Pulsatile flow, Turbulent fluid flow modeling (1)
- Adenosine receptors (1)
- Arterial spin labeling (1)
- Astrocytes, biocompatibility, biomaterials, glial scar, nanopatterns, neural electrodes (1)
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- Beveled, Contact Pressure, Osteochondral Defect, Pressure Distribution, Well-Shouldered (1)
- Bone, Calcium Phosphate, Crystallography, Hydroxyapatite Collagen Composite, Mechanical Properties, Polarized Light Microscopy (1)
- Caffeine (1)
- Cerebral blood flow (1)
- Chemometrics (1)
- Computer-assisted surgery (1)
- FIT Cap, Fitment, Football Helmet Performance, Head Impact Telemetry (HIT) System, Helmet, Tightness of Fit (1)
- Image guidance (1)
- Raman spectroscopy (1)
- Robot calibration (1)
- Sensor integration (1)
- Surface righting (1)
- Traumatic brain injury (1)
Articles 1 - 9 of 9
Full-Text Articles in Biomedical Engineering and Bioengineering
Traumatic Brain Injury Induced Cerebral Blood Flow Changes - A Potential Role For Caffeine, Sharath Chandra Reddy Bandaru
Traumatic Brain Injury Induced Cerebral Blood Flow Changes - A Potential Role For Caffeine, Sharath Chandra Reddy Bandaru
Wayne State University Theses
Traumatic brain injury (TBI) is a global health problem with significant socio-economic costs. Closed head TBIs are one of the major causes of physical disability and cognitive disorder in young adults and a leading cause of death in children.
Alteration in cerebral blood flow due to an impaired autoregulation is one of the most common consequences of TBI. However, studies related to understanding the temporal changes in CBF following TBI in experimental models are limited. The few available studies report acute reduction in CBF following TBI; knowledge related to CBF changes at sub-acute periods extending to 7 days after TBI …
Raman Spectroscopy And Diffuse Reflectance Spectroscopy For Diagnosis Of Human Cancer And Acanthosis Nigricans, Suneetha Devpura
Raman Spectroscopy And Diffuse Reflectance Spectroscopy For Diagnosis Of Human Cancer And Acanthosis Nigricans, Suneetha Devpura
Wayne State University Dissertations
Cancer and diabetes are common chronic diseases in today's world causing numerous deaths in adults as well as children. Most common types of cancers in adults include prostate, lung, breast, colorectal and head and neck squamous cell carcinoma, while among children; leukemia, and brain and central nervous system cancers are quite common. In each of these cases, early detection of the cancer or disease dramatically increases the chances of successful treatment. In recent years, there has been much interest in using Raman spectroscopy and diffuse reflectance spectroscopy as analytical optical spectroscopic methods for early diagnosis of diseases. Raman spectroscopy can …
Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier
Enhancing The Mechanical Properties Of A Hydroxyapatite-Collagen Bone Surrogate, Richard Franz Banglmaier
Wayne State University Dissertations
The synthesis of biomimetic hydroxyapatite-collagen composites is desirable from the perspective of graft elimination and load-bearing support when treating damaged or diseased bone. Bone is an organized network of carbonated hydroxyapatite mineralized collagen, whose strength and toughness is dependent on the organized array of mineralized collagen fibers that align with applied physiologic stresses. The apatitic calcium phosphate phase, hydroxyapatite, is promising for the biomimetic mineralization of collagen. Hydroxyapatite-collagen composites are osteoconductive and resorbable. However, the mechanical properties of these composites are one or more orders of magnitude less than bone. The aim of this study was to produce a bone-like …
Football Helmet Fitment And Its Effect On Helmet Performance, Ron Jadischke
Football Helmet Fitment And Its Effect On Helmet Performance, Ron Jadischke
Wayne State University Theses
A method and system to objectively quantify helmet fitment was designed and developed. It measures the pressure between the energy-absorbing material in the helmet and the athlete's head. This system is also capable of measuring surface pressure during impact events. A volunteer-based field study was conducted to quantify how helmets were fitting athletes in a real-life setting. The helmets fit athletes in varying degrees of tightness and evenness. Most athletes (59%) had the highest pressures in the frontal area and 29% had the highest pressure in the occipital area. A large-sized helmet on the Hybrid III headform represented how most …
Contact Pressure Distribution Of Osteochondral Defects Of The Knee: Effects Of Non-Vertical Walls, Scott Ensminger
Contact Pressure Distribution Of Osteochondral Defects Of The Knee: Effects Of Non-Vertical Walls, Scott Ensminger
Wayne State University Theses
Purpose: To examine the relationship between well-shouldered osteochondral defects and
defects of different geometries by studying their effects on rim stress concentration and
load redistribution in the human knee.
Methods: Ten fresh-frozen cadaveric knees were mounted at 30° of flexion in a materials
testing machine. Digital electronic pressure sensors were placed in the medial and lateral
compartments of the knee. Dynamic pressure readings were recorded throughout the
loading and holding phases as each knee was loaded to 700N and held for 5 seconds.
Artificial defects were created in each knee to simulate well-shouldered defects and
beveled-defects. Loading was repeated for …
Neurophysiological Changes In Spinal Nerve Roots Subjected To Tensile Loading At Several Strain Rates, Gurjiwan Singh Virk
Neurophysiological Changes In Spinal Nerve Roots Subjected To Tensile Loading At Several Strain Rates, Gurjiwan Singh Virk
Wayne State University Theses
ABSTRACT:
Spinal nerve roots have been implicated in many types of traumatic injuries such as motor vehicle accidents, falls, and sports injury, causing damage to brachial plexus and lumbosacral plexus. They have also been involved in lower back pain, disc herniation or protrusions, sciatica, and traumatic birth delivers such as shoulder dystocia. These roots undergo tension, resulting in traumatic axonal injury (TAI), which is also one of the consequences of traumatic brain injury (TBI). Every year about 2 million cases of TBI are reported nationwide with variable neurological deficits. Thus, it is important to understand the neurophysiological response and injury …
Numerical Simulation And Experimentation Of Pulsatile Flows In Axisymmetric Arterial Models, Tadesse Gebreegziabher
Numerical Simulation And Experimentation Of Pulsatile Flows In Axisymmetric Arterial Models, Tadesse Gebreegziabher
Wayne State University Dissertations
ABSTRACT
NUMERICAL SIMULATION AND EXPERIMENTATION OF PULSATILE FLOWS IN AXISYMMETRIC ARTERIAL MODELS
by
TADESSE GEBREEGZIABHER
December 2011
Co-advisors: 1. Dr. Emmanuel Ayorinde 2. Dr. Trilochan Singh
Major: Mechanical Engineering
Degree: Doctor of Philosophy
The primary motivation for this dissertation is the fluid flow and structural response to unsteady blood flow in the human body. The research work is a synergistic merging of numerical simulation and experimentation. For the experiments, an all-encompassing, highly flexible experimental apparatus was designed and fabricated to facilitate a wide range of operating conditions, the range of which was chosen to accommodate mammalian cardiovascular system for both …
Studying The Glial Cell Response To Biomaterials And Surface Topography For Improving The Neural Electrode Interface, Evon S. Ereifej
Studying The Glial Cell Response To Biomaterials And Surface Topography For Improving The Neural Electrode Interface, Evon S. Ereifej
Wayne State University Dissertations
Neural electrode devices hold great promise to help people with the restoration of lost functions, however, research is lacking in the biomaterial design of a stable, long-term device. Current devices lack long term functionality, most have been found unable to record neural activity within weeks after implantation due to the development of glial scar tissue (Polikov et al., 2006; Zhong and Bellamkonda, 2008). The long-term effect of chronically implanted electrodes is the formation of a glial scar made up of reactive astrocytes and the matrix proteins they generate (Polikov et al., 2005; Seil and Webster, 2008). Scarring is initiated when …
Techniques For Sensor-Integrated Robotic Systems: Raman Spectra Analysis, Image Guidance, And Kinematic Calibration, Luke Anthony Reisner
Techniques For Sensor-Integrated Robotic Systems: Raman Spectra Analysis, Image Guidance, And Kinematic Calibration, Luke Anthony Reisner
Wayne State University Dissertations
Robotics and sensor technology have made impressive advancements over the years. There are now robotic systems that help perform surgeries or explore the surface of Mars, and there are sensors that detect trace amounts of explosives or identify diseased human tissue. The most powerful systems integrate robots and sensors, which are natural complements to each other. Sensors can provide information that might otherwise be unavailable due to indirect robotic manipulation (e.g., images of the target environment), and robots can provide suitably precise positioning of an analytical sensor.
To have an effective sensor-integrated robotic system, multiple capabilities are needed in the …