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Quantitative Evaluation Of Redox Processes In Intact Rat Lungs And Endothelial Cells And The Effect Of Hyperoxia, Zhuohui Gan
Quantitative Evaluation Of Redox Processes In Intact Rat Lungs And Endothelial Cells And The Effect Of Hyperoxia, Zhuohui Gan
Dissertations (1934 -)
A common initial treatment of hypoxemia in patients with lung failure secondary to acute lung injury (e.g., adult respiratory distress syndrome) is oxygen (O2) therapy (hyperoxia). However, prolonged O2 therapy causes lung O2 toxicity, which can further impair lung functions. The rat model of lung O2 toxicity replicates key features of human lung O2 toxicity. In addition, rats develop tolerance or susceptibility to 100% O2 by pre-exposing them to 85% O2 (hyper-85) or 60% O2 (hyper-60) for 7 days, respectively. Therefore, the long-term objectives of this study are to elucidate mechanisms …