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Characterizing Neurotransmitter Receptor Activation With A Perturbation Based Decomposition Method, Stephen Gregory Jue
Characterizing Neurotransmitter Receptor Activation With A Perturbation Based Decomposition Method, Stephen Gregory Jue
Master's Theses
The characterization of postsynaptic potentials, in terms of neurotransmitter receptor activation, is of clinical significance because information associated with receptor activation can be used in the diagnosis and study of neurological disorders. Single-unit recordings provide a method of measuring postsynaptic potentials in neurons using a microelectrode system, but yield no detailed information regarding the neurotransmitter receptors that contribute to the potential. To determine the types of neurotransmitter receptors that result in a compound postsynaptic potential from a microelectrode reading, decomposition of the potential is necessary. In this work, a perturbation-based decomposition method developed by R. Szlavik is evaluated for this …