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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Controlling Strain Energy Density In 3d Cellular Collagen Constructs During Complex Loads, Katherine Hollar Dec 2019

Controlling Strain Energy Density In 3d Cellular Collagen Constructs During Complex Loads, Katherine Hollar

Boise State University Theses and Dissertations

Mechanical stimulation applied to damaged soft tissues, such as ligament, can promote tissue remodeling to accelerate healing. To help identify treatments that encourage ligament healing, bioreactors have been designed to subject 3D cellularized constructs to various loading conditions in order to determine the mechanical mechanisms that trigger cell-mediated repair. An innovative approach is to use a bioreactor to apply controlled states of biaxial stress to study the effects of strain energy density and distortion energy on cell activity. Tissue distortion has been linked to changes in the structure and function of ligament, yet the specific impact of distortion energy on …


Effect Of Corrective Surgery On Lower Limb Mechanics In Patients With Crouch Gait, Adelle Milholland Dec 2019

Effect Of Corrective Surgery On Lower Limb Mechanics In Patients With Crouch Gait, Adelle Milholland

Boise State University Theses and Dissertations

Crouch gait a progressively degrading gait deviation associated with the neurological disorder cerebral palsy. If left untreated it can lead to anterior knee pain and a loss of ambulation. At present there exists no agreed upon metric for determining the surgical procedures used to treat crouch gait and there is insufficient means to analytically compare the results of different procedures. The aims of this thesis work were to create a pipeline to transform a patient’s gait analysis data into a finite element model, develop a model of sufficient complexity to evaluate a range of outcomes by which to judge the …


The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie Aug 2019

The Effect Of Implant Conformity On Muscle Force Requirements In The Implanted Knee, Grace Mcconnochie

Boise State University Theses and Dissertations

Implant geometry is a significant factor in determining knee stability and patient satisfaction following total knee replacement (TKR). Ineffective muscle recruitment, impaired joint functionality and increased implant wear are consequences of an unstable knee replacement. Current knee laxity evaluation techniques are limited in their ability to account for the muscular response to knee instability. This study utilizes a subject specific lower-body musculoskeletal finite element (FE) model with dynamic muscle loading to evaluate implant laxity during activities of daily living. The effect of varying implant conformity on the muscle forces required to maintain a target kinematic profile during simulated laxity testing …


Development Of A Statistical Shape-Function Model Of The Implanted Knee For Real-Time Prediction Of Joint Mechanics, Kalin Gibbons Aug 2019

Development Of A Statistical Shape-Function Model Of The Implanted Knee For Real-Time Prediction Of Joint Mechanics, Kalin Gibbons

Boise State University Theses and Dissertations

Outcomes of total knee arthroplasty (TKA) are dependent on surgical technique, patient variability, and implant design. Non-optimal design or alignment choices may result in undesirable contact mechanics and joint kinematics, including poor joint alignment, instability, and reduced range of motion. Implant design and surgical alignment are modifiable factors with potential to improve patient outcomes, and there is a need for robust implant designs that can accommodate patient variability. Our objective was to develop a statistical shape-function model (SFM) of a posterior stabilized implant knee to instantaneously predict output mechanics in an efficient manner. Finite element methods were combined with Latin …


Happy Hours Are A Godsend, Krishna Pakala, Diana Bairaktarova, Samantha Schauer Jun 2019

Happy Hours Are A Godsend, Krishna Pakala, Diana Bairaktarova, Samantha Schauer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Office hours that happen in a virtual environment are called virtual office hours. This type of student-faculty interaction can be easily hosted from a faculty computer/mobile device/tablet. With an invitation, students can login to the online session and join their instructor and peers in a virtual space. Using mobile technologies, students can join virtual office hours from a variety of locations including a library, outdoors, on a commute ride home, while caring for children, eating dinner, and even while grocery shopping. Virtual office hours allow for more flexibility of student-faculty interaction. They are an alternative to traditional office hours. This …


Work In Progress: First-Year Engineering College Students: Value Created From Participating In A Living/Learning Community, Krishna Pakala, Kim M.B. Tucker, Samantha Schauer Jun 2019

Work In Progress: First-Year Engineering College Students: Value Created From Participating In A Living/Learning Community, Krishna Pakala, Kim M.B. Tucker, Samantha Schauer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

This Work in Progress paper examines how to capture the perceived value obtained from firstyear engineering college students (FYECS) from participating in the Engineering and Innovation Residential College (EIRC), a living learning community (LLC). People are social by nature and thrive through collaborating and living with others who share similar passions; however, oftentimes FYECS do not have a community of like-minded peers where support, innovation, discourse, and collaboration can take place. Adding to FYECS struggles is the fact that many do not have a mentor in their related field and are unable to start building their professional repertoire, network, technical …


Review Of Educational Technology: Closing The Gap Between Modern Technology And The College Engineering Classroom, David Pinkerton, Krishna Pakala Mar 2019

Review Of Educational Technology: Closing The Gap Between Modern Technology And The College Engineering Classroom, David Pinkerton, Krishna Pakala

Mechanical and Biomedical Engineering Faculty Publications and Presentations

This paper aggregates information from past and current studies regarding the implementation of technology in engineering classrooms and identifies the most promising ideas, technologies, and techniques. This paper provides insight into best practices for implementing technologies to improve the education of engineering students. This paper provides recommendations to adopt non-traditional teaching methods. Educational tools and techniques are evaluated on the basis of: Adoption and Assimilation, Access, Community, Intellectual Presence, Student Perception, and Development of Social and Professional Skills. Best practices are highlighted with descriptions of the technologies and techniques that were found most promising.


Recovery Of Stem Cell Proliferation By Low Intensity Vibration Under Simulated Microgravity Requires Linc Complex, H. Touchstone, R. Bryd, S. Loisate, M. Thompson, X. Pu, R. Beard, J. T. Oxford, G. Uzer Jan 2019

Recovery Of Stem Cell Proliferation By Low Intensity Vibration Under Simulated Microgravity Requires Linc Complex, H. Touchstone, R. Bryd, S. Loisate, M. Thompson, X. Pu, R. Beard, J. T. Oxford, G. Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Mesenchymal stem cells (MSC) rely on their ability to integrate physical and spatial signals at load bearing sites to replace and renew musculoskeletal tissues. Designed to mimic unloading experienced during spaceflight, preclinical unloading and simulated microgravity models show that alteration of gravitational loading limits proliferative activity of stem cells. Emerging evidence indicates that this loss of proliferation may be linked to loss of cellular cytoskeleton and contractility. Low intensity vibration (LIV) is an exercise mimetic that promotes proliferation and differentiation of MSCs by enhancing cell structure. Here, we asked whether application of LIV could restore the reduced proliferative capacity seen …