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Full-Text Articles in Biomedical Engineering and Bioengineering

Application Of Sub-Micrometer Vibrations To Mitigate Bacterial Adhesion, Will R. Paces, Hal Holmes, Eli Vlaisavljevich, Katherine L. Snyder, Ee Lim Tan, Rupak Rajachar, Keat Ghee Ong Mar 2014

Application Of Sub-Micrometer Vibrations To Mitigate Bacterial Adhesion, Will R. Paces, Hal Holmes, Eli Vlaisavljevich, Katherine L. Snyder, Ee Lim Tan, Rupak Rajachar, Keat Ghee Ong

Michigan Tech Publications

As a prominent concern regarding implantable devices, eliminating the threat of opportunistic bacterial infection represents a significant benefit to both patient health and device function. Current treatment options focus on chemical approaches to negate bacterial adhesion, however, these methods are in some ways limited. The scope of this study was to assess the efficacy of a novel means of modulating bacterial adhesion through the application of vibrations using magnetoelastic materials. Magnetoelastic materials possess unique magnetostrictive property that can convert a magnetic field stimulus into a mechanical deformation. In vitro experiments demonstrated that vibrational loads generated by the magnetoelastic materials significantly …


Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar Feb 2012

Fabrication Of Biocompatible, Vibrational Magnetoelastic Materials For Controlling Cellular Adhesion, Hal Holmes, Ee Lim Tan, Keat Ghee Ong, Rupak Rajachar

Michigan Tech Publications

This paper describes the functionalization of magnetoelastic (ME) materials with Parylene-C coating to improve the surface reactivity to cellular response. Previous study has demonstrated that vibrating ME materials were capable of modulating cellular adhesion when activated by an externally applied AC magnetic field. However, since ME materials are not inherently biocompatible, surface modifications are needed for their implementation in biological settings. Here, the long-term stability of the ME material in an aqueous and biological environment is achieved by chemical-vapor deposition of a conformal Parylene-C layer, and further functionalized by methods of oxygen plasma etching and protein adsorption. In vitro cytotoxicity …


Design, Fabrication, And Implementation Of A Wireless, Passive Implantable Pressure Sensor Based On Magnetic Higher-Order Harmonic Fields, Ee Lim Tan, Andrew Derouin, Brandon D. Pereles, Keat Ghee Ong Oct 2011

Design, Fabrication, And Implementation Of A Wireless, Passive Implantable Pressure Sensor Based On Magnetic Higher-Order Harmonic Fields, Ee Lim Tan, Andrew Derouin, Brandon D. Pereles, Keat Ghee Ong

Michigan Tech Publications

A passive and wireless sensor was developed for monitoring pressure in vivo. Structurally, the pressure sensor, referred to as the magneto-harmonic pressure sensor, is an airtight chamber sealed with an elastic pressure membrane. A strip of magnetically-soft material is attached to the bottom of the chamber and a permanent magnet strip is embedded inside the membrane. Under the excitation of an externally applied AC magnetic field, the magnetically-soft strip produces a higher-order magnetic signature that can be remotely detected with an external receiving coil. As ambient pressure varies, the pressure membrane deflects, altering the separation distance between the magnetically-soft strip …


Implantable Biosensors For Real-Time Strain And Pressure Monitoring, Ee Lim Tan, Brandon D. Pereles, Brock Horton, Ranyuan Shao, Mohammed Zourob, Keat Ghee Ong Oct 2008

Implantable Biosensors For Real-Time Strain And Pressure Monitoring, Ee Lim Tan, Brandon D. Pereles, Brock Horton, Ranyuan Shao, Mohammed Zourob, Keat Ghee Ong

Michigan Tech Publications

Implantable biosensors were developed for real-time monitoring of pressure and strain in the human body. The sensors, which are wireless and passive, consisted of a soft magnetic material and a permanent magnet. When exposed to a low frequency AC magnetic field, the soft magnetic material generated secondary magnetic fields that also included the higher-order harmonic modes. Parameters of interest were determined by measuring the changes in the pattern of these higher-order harmonic fields, which was achieved by changing the intensity of a DC magnetic field generated by a permanent magnet. The DC magnetic field, or the biasing field, was altered …


A Wireless, Passive Sensor For Quantifying Packaged Food Quality, Ee Lim Tan, Wen Ni Ng, Ranyuan Shao, Brandon D. Pereles, Keat Ghee Ong Sep 2007

A Wireless, Passive Sensor For Quantifying Packaged Food Quality, Ee Lim Tan, Wen Ni Ng, Ranyuan Shao, Brandon D. Pereles, Keat Ghee Ong

Michigan Tech Publications

This paper describes the fabrication of a wireless, passive sensor based on aninductive-capacitive resonant circuit, and its application for in situ monitoring of thequality of dry, packaged food such as cereals, and fried and baked snacks. The sensor ismade of a planar inductor and capacitor printed on a paper substrate. To monitor foodquality, the sensor is embedded inside the food package by adhering it to the package’sinner wall; its response is remotely detected through a coil connected to a sensor reader. Asfood quality degrades due to increasing humidity inside the package, the paper substrateabsorbs water vapor, changing the capacitor’s capacitance …