Biomedical Engineering and Bioengineering Commons^™

Prostate Cancer Detection Using Combined Autofluorescence And Light Reflectance Spectroscopy: Ex Vivo Study Of Human Prostates, Vikrant Sharma, Ephrem O. Olweny, Payal Kapur, Jeffrey A. Cadeddu, Claus G. Roehrborn, Hanli Liu

Bioengineering Faculty Publications

This study was conducted to evaluate the capability of detecting prostate cancer (PCa) using auto-fluorescence lifetime spectroscopy (AFLS) and light reflectance spectroscopy (LRS). AFLS used excitation at 447 nm with four emission wavelengths (532, 562, 632, and 684 nm), where their lifetimes and weights were analyzed using a double exponent model. LRS was measured between 500 and 840 nm and analyzed by a quantitative model to determine hemoglobin concentrations and light scattering. Both AFLS and LRS were taken on n = 724 distinct locations from both prostate capsular (nc = 185) and parenchymal (np = 539) tissues, including PCa tissue, …