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Full-Text Articles in Biomedical Engineering and Bioengineering
Protoporphyrin Ix (Ppix)-Conjugated Self-Lighting Nanoparticles For Photodynamic Therapy: Synthesis And Characterization, Homa Homayoni
Protoporphyrin Ix (Ppix)-Conjugated Self-Lighting Nanoparticles For Photodynamic Therapy: Synthesis And Characterization, Homa Homayoni
Bioengineering Dissertations
In Photodynamic therapy (PDT) PDT, cancer destruction relies on applying a photosensitizing drug (PS) followed by light. Absorbed light can activate the PS to transfer energy to existing molecules and substrates or to oxygen to generate singlet oxygen which are highly toxic to cells. Protophorphyrin IX (PpIX) is a photosensitizers (PSs) which has FDA approval and an absorbance near the Soret band which is 10 times stronger than the absorbance in Q-band (600nm). Our goal was to design a modality to eliminate of external blue light in addition to increasing the drug's water dispersion which finally may result in enhancing …
Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models, Zi-Jing Lin
Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models, Zi-Jing Lin
Bioengineering Dissertations
Stroke, including ischemic stroke and hemorrhagic stroke, is the major leading cause of death in the United States. More than 80 percent of stroke patients are diagnosed with ischemic stroke, which usually results from blockage of artery in the brain by thrombosis or arterial embolism. Animal Models, which permit powerful genetic and molecular approaches, provide an essential tool to study and understand the basic processes and potential therapeutic interventions for this disease. Significant efforts have been made to closely mimic the changes that occur in humans during and after stroke using animal models. Recent development on near infrared (NIR) diffuse …
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods, Shu-Fen Tseng
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods, Shu-Fen Tseng
Bioengineering Dissertations
DAB2IP is correlated to the risk of aggressive prostate cancer and loss of DAB2IP not only leads to epithelial-to-mesenchymal transition (EMT), but also makes cells radioresistant. These observations support the notion that improved knowledge of DAB2IP involvement in cellular pathways could be of help to cancer therapy. The goal of this work was to enable the study of how DAB2IP and some of its known key molecular partners interact in the cell by a combination of molecular biology techniques and recently reported quantitative fluorescence microscopy methods. The first part of this work was dedicated on investigating the interaction of DAB2IP …
Development Of Non-Invasive Methods For Imaging Inflammatory Response, Yi-Ting Tsai
Development Of Non-Invasive Methods For Imaging Inflammatory Response, Yi-Ting Tsai
Bioengineering Dissertations
Persistent inflammatory cell reactions are responsible for the pathogenesis of a variety of inflammatory diseases. Although many non-invasive imaging methods have been used in the clinics to monitor the extent of inflammatory responses, almost all of them are based on indirect detection of inflammation-associated anatomical or structure changes of tissues and organs. To fill the gap, our laboratory has focused research efforts on detecting different processes of inflammatory responses. Our results can be summarized in the sequence of inflammatory responses - edema formation, inflammatory cell recruitment, inflammatory product release, and cell death. Shortly after medical device implantation or injury, edema …
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts, Srikanth Vasudevan
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts, Srikanth Vasudevan
Bioengineering Dissertations
Peripheral nerve injuries that arise as a result of trauma, tumor excision or birth can adversely affect the quality of patient life, leading to lifelong disabilities in some cases. Autologous nerve grafts are the clinical "gold standard" for long gap nerve repair, and allogeneic nerve grafts are considered the next best treatment option. Despite having numerous benefits, autologous nerve grafts are associated with limited supply, longer operation time, risk of infection, painful neuroma formation and most importantly, loss of function at the donor site. Allogeneic nerve grafts require transient immunosuppression, which exposes the patients to risks of infection, toxicity and …
The Pivotal Role Of Fibrocytes On Foreign Body Reactions, David William Baker
The Pivotal Role Of Fibrocytes On Foreign Body Reactions, David William Baker
Bioengineering Dissertations
Fibrocytes are circulating connective tissue precursor cells that were first described in 1994 by Bucala et al. as mediators of the innate immune response [1]. Recently the notion of a fibrocyte has not only gained widespread acceptance, but these cells have been identified to participate in a number of disease and pathologic states including aberrant wound repair, fibrosis of organs, cardiovascular disease, and even normal aging. Despite these advancements, little was known about the response of these dynamic cells to biomaterial implants and foreign body reactions. The main focus of my thesis work has therefore focused on investigating fibrocyte-mediate responses, …
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury, Jennifer Elisabeth Stearns Bell
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury, Jennifer Elisabeth Stearns Bell
Bioengineering Dissertations
Scoliosis corrective surgery requires the application of multidirectional stress forces to the spinal cord, including those of distraction, in addition to the application of fixation rods for correction of the curved spine deformity. If excessive, spine distraction may result in the development of new neurologic deficits, some as severe as permanent paralysis. Intraoperative monitoring is used to alert the surgeon to possible complications; however, the complex nature of spinal cord injury (SCI) involves a primary mechanical insult to the tissue and/or vasculature that may go undetected by monitoring. This is followed by the activation of widespread secondary injury mechanisms. The …