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Full-Text Articles in Biomedical Engineering and Bioengineering
Methodology Development For The Implementation Ofmicrofluidic Mixers, Tahir Butt, Gautam Mahajan
Methodology Development For The Implementation Ofmicrofluidic Mixers, Tahir Butt, Gautam Mahajan
Undergraduate Research Posters 2018
Microfluidic platforms have been widely regarded as defining technologies for the development of chemical and biological synthesis and analysis systems, due to benefits associated with reduced reactant consumption, increases by orders of magnitude of the surface-to-volume ratios, and greatly enhanced control over reactions variables such as temperature and pressure. However, one of the bottlenecks for their wide application is the difficulty in achieving mixing, given the typical laminar flows in these systems. In this work we implement experimentally, various strategies using geometrical features to control the fluid motion and induce stirring flows. The mixers are fabricated using soft-lithography in PDMS …
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis, Alexa Roberts
Implementation Of A Reverse Staggered-Herringbone Microfluidic Mixer For High-Throughput Polymeric Nanoparticles Synthesis, Alexa Roberts
Undergraduate Research Posters 2018
The goal of this research is to implement and optimize the operating conditions of a microfluidic mixer to synthesize polymeric nanoparticles (NPs) in a high-throughput fashion. Using a reverse staggered-herringbone microfluidic mixer that we recently designed, the effects of experimental conditions such as flowrate and reactant composition on NP characteristics were investigated and optimized. The device design allowed for physical contact between two streams of fluids – one containing poly(lactic-co-glycolic acid; PLGA) in acetonitrile and the other deionized water, to allow for efficient mixing and NP precipitation to occur. The resulting NPs were characterized using dynamic light scattering (DLS) and …
Boundary Effects On The Locomotion Of Active Janus Particles, Marola W. Issa, Nicky R. Baumgartner
Boundary Effects On The Locomotion Of Active Janus Particles, Marola W. Issa, Nicky R. Baumgartner
Undergraduate Research Posters 2018
Self-propelled or “active” micrometer scale particles are capable of supplying local mechanical work, necessary for microscale cargo delivery and useful in other applications within bioimaging and sensing. Research in the last decade has focused on developing, measuring, and manipulating the locomotion mechanisms of active particles in simple environments. However, many applications will be in complex environments with nearby boundaries or variations in physiochemical cues. This poster reports the directed motion of platinum coated polystyrene particles at infinite dilution in the presence of H2O2, which acts as a fuel to drive motion. A transport mechanism called “diffusiophoresis” drives motion of the …
P1: Using Modified Dean Flow Designs To Increase Mixing Performance, Joshua Clark
P1: Using Modified Dean Flow Designs To Increase Mixing Performance, Joshua Clark
Undergraduate Research Posters 2017
We are using numerical solutions for the Navier-Stokes equations and the concentration - diffusion equation to model fluid flow and reactant distribution in serpentine type channels for micromixers/microreactors development. These mixers exploit centripetal forces on the fluid to induce cross-sectional fluid mixing, aka Dean flows. Various modifications are used to increase the mixing character of these crosssectional flows. We found that the performance of these mixers exceeds that of unmodified channels and we currently assess their performance relative to other state of the art methodologies used to induce mixing on the microscale.
Going Green: Experimental Adaptation Of Scenedesmus Dimorphus To Marine Conditions, Mohammed Khalil
Going Green: Experimental Adaptation Of Scenedesmus Dimorphus To Marine Conditions, Mohammed Khalil
Undergraduate Research Posters 2017
Algae has gained some interest as the need for alternative fuels becomes more pressing. Reliance on fossil fuels is causing our environment and economy harm, and is not sustainable moving forward. Lipid rich algae strains can be used in the production of biofuels, and provide an alternative fuel source. One challenge facing the prospect of algae as a fuel source is that lipid rich algae grows exclusively in freshwater. Considering the scarcity and cost to use freshwater for algae growth, interest has grown in the possibility of adapting lipid rich, freshwater algae to a seawater environment. Seawater can have up …
P2: Implementation Of Groove Based Designs For Engineering Fluid Flow In Micromixers, Tahir Butt
P2: Implementation Of Groove Based Designs For Engineering Fluid Flow In Micromixers, Tahir Butt
Undergraduate Research Posters 2017
Mixing on microscale is important for the development of miniaturized chemical reactors that use small quantities of reactants and allow better control over the reaction conditions and products. Nevertheless, achieving rapid mixing in this type of micro-reactors is challenging due to the lack of turbulence and slow diffusion on the microscale. In this work we implement micromixers designs based on surface groove/ridge patterns targeted at inducing cross-sectional flows that both extend the interface between the different reactants, as well as induce chaotic advection. We discuss the fabrication of these structures using soft-lithography in PDMS employing a mold and their optical …