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Cleveland State University

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Articles 1 - 30 of 153

Full-Text Articles in Biomedical Engineering and Bioengineering

Thenar Muscle And Transverse Carpal Ligament Relationship, Jeremy Granieri Loss Jan 2019

Thenar Muscle And Transverse Carpal Ligament Relationship, Jeremy Granieri Loss

ETD Archive

The transverse carpal ligament (TCL) acts as a partial origin for the thenar muscles (abductor pollicis brevis (APB), flexor pollicis brevis (FPB), opponens pollicis (OPP)). The attachment between the thenar muscles and TCL implies a relationship between the tissues. The thenar muscles rely on their origins for thumb motion and force production. However, individual thenar origin information is lacking. Further information regarding the anatomical relationship between the individual thenar muscles and TCL may provide insight into thenar muscle function. In addition, the TCL responds to thenar muscle contraction as shown by volar migration of the TCL during various thumb movements ...


Three-Dimensional Human Neural Stem Cell Culture For High-Throughput Assessment Of Developmental Neurotoxicity, Pranav Joshi Jan 2019

Three-Dimensional Human Neural Stem Cell Culture For High-Throughput Assessment Of Developmental Neurotoxicity, Pranav Joshi

ETD Archive

Only a few hundred of compounds, among tens of thousands of commercially available compounds, have been tested for developmental neurotoxicity (DNT) due to the limitations of current guidelines for DNT which are based entirely on in vivo experiments. In vivo studies are highly expensive and time-consuming, which often do not correlate to human outcomes. There is a key gap in our ability to predict in vivo outcomes accurately and robustly using in vitro assays. This is particularly the case for predicting the toxicity of chemicals on the developing human brains. Conventional in vitro assays are typically performed in two-dimensional (2D ...


Compensation For Inertial And Gravity Effects In A Moving Force Platform, Sandra K. Hnat, Ben J.H. Van Basten, Antonie J. Van Den Bogert Jun 2018

Compensation For Inertial And Gravity Effects In A Moving Force Platform, Sandra K. Hnat, Ben J.H. Van Basten, Antonie J. Van Den Bogert

Mechanical Engineering Faculty Publications

Force plates for human movement analysis provide accurate measurements when mounted rigidly on an inertial reference frame. Large measurement errors occur, however, when the force plate is accelerated, or tilted relative to gravity. This prohibits the use of force plates in human perturbation studies with controlled surface movements, or in conditions where the foundation is moving or not sufficiently rigid. Here we present a linear model to predict the inertial and gravitational artifacts using accelerometer signals. The model is first calibrated with data collected from random movements of the unloaded system and then used to compensate for the errors in ...


Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth Jan 2018

Modeling Liver Diseases Using Hepatic Cell Microarrays, Alexander David Roth

ETD Archive

Hepatocellular carcinoma (HCC) is an invasive and aggressive cancer of the liver that arises due to chronic cirrhosis. Research into understanding HCC has focused on two-dimensional (2D) and three-dimensional (3D) technologies to simulate the liver microenvironment and use animal models to model how HCC affects the rest of the body. 3D hydrogel models are desired because they can mimic the transport behavior observed in vivo by structurally mimicking the extracellular matrix (ECM) without the ethical concerns of animal models. However, hydrogels can be toxic to cells and require optimal procedures for appropriate handling. In this study, we created 3D models ...


The Effect Of Cognitive Limb Embodiment On Vascular Physiological Response, Hala Elsir Mustafa Osman Jan 2018

The Effect Of Cognitive Limb Embodiment On Vascular Physiological Response, Hala Elsir Mustafa Osman

ETD Archive

The rubber hand illusion (RHI) is a visual-tactile perceptual illusion commonly used to study body ownership. In this paradigm, a rubber hand is positioned in front of a participant, and the person’s real hand is hidden from sight behind a barrier. When the real hand and the rubber hand are stroked synchronously, individuals perceive the rubber hand as if it were their own; it becomes “embodied.” This illusory experience of body ownership is associated with multimodal integration of touch and vision. From these visual-tactile-cognitive mechanisms, we establish that our hands belong to us when what we see matches what ...


Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros Jan 2018

Advanced Manufacturing Of Titanium Alloys For Biomedical Applications, Nicholas C. Mavros

ETD Archive

In metallurgy, Titanium has been a staple for biomedical purposes. Its low toxicity and alloying versatility make it an attractive choice for medical applications. However, studies have shown the difference in elastic modulus between Titanium alloys (116 GPa) and human bone (40-60 GPa) contribute to long term issues with loose hardware fixation. Additionally, long term studies have shown elements such as Vanadium and Aluminum, which are commonly used in Ti-6Al-4V biomedical alloys, have been linked to neurodegenerative diseases like Alzheimers and Parkinsons. Alternative metals known to be less toxic are being explored as replacements for alloying elements in Titanium alloys ...


Neuromuscular Reflex Control For Prostheses And Exoskeletons, Sandra K. Hnat Jan 2018

Neuromuscular Reflex Control For Prostheses And Exoskeletons, Sandra K. Hnat

ETD Archive

Recent powered lower-limb prosthetic and orthotic (P/O) devices aim to restore legged mobility for persons with an amputation or spinal cord injury. Though various control strategies have been proposed for these devices, specifically finite-state impedance controllers, natural gait mechanics are not usually achieved. The goal of this project was to invent a biologically-inspired controller for powered P/O devices. We hypothesize that a more muscle-like actuation system, including spinal reflexes and vestibular feedback, can achieve able-bodied walking and also respond to outside perturbations. The outputs of the Virtual Muscle Reflex (VMR) controller are joint torque commands, sent to the ...


Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron Jan 2018

Characterizing The Effects Of High-Intensity Exercise On Balance And Gait Under Dual-Task Conditions In Parkinson’S Disease, El Iva Baron

ETD Archive

Parkinson’s disease (PD) is a neurodegenerative disorder, characterized by four cardinal motor symptoms including bradykinesia, tremor, rigidity, and postural instability, and non-motor symptoms including cognitive impairment. Daily activities, such as walking and maintaining balance, are impacted due to impairments in motor function, and are further exacerbated with the addition of cognitive loading, or dual-tasking (DT). High-intensity exercise has demonstrated centrally-mediated improvements of PD symptoms, with additional positive effects on overall health. The goal of this project was to identify changes in dynamic balance recovery and gait function under conditions with and without increased cognitive load after a high-intensity exercise ...


High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang Jan 2018

High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang

ETD Archive

The U.S Environmental Protection Agency (EPA) launched the Transform Tox Testing Challenge in 2016 with the goal of developing practical methods that can be integrated into conventional high-throughput screening (HTS) assays to better predict the toxicity of parent compounds and their metabolites in vivo. In response to this need and to retrofit existing HTS assays for assessing metabolism-induced toxicity of compounds, we have developed a 384-pillar plate that is complementary to traditional 384-well plates and ideally suited for culturing human cells in three dimensions (3D) at a microscale. Briefly, human embryonic kidney (HEK) 293 cells in a mixture of ...


Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag Jan 2018

Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag

ETD Archive

Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal epithelia adjacent to a cyst. We hypothesize that in normal epithelia near a cyst, the stabilization of Hypoxia Inducible Factor 1a (HIF1a), a major regulator of cellular response to hypoxia, can cause altered paracellular and transcellular transport, transforming a normal absorptive phenotype to a secretory and paracellularly leaky phenotype, leading to cyst expansion. Using 100 µmol/L cobalt chloride (CoCl2), HIF1a was stabilized in cellular nucleus of a mouse cortical collecting duct cell line (mCCD ...


Predictive Simulations Of Gait And Their Application In Prosthesis Design, Anne D. Koelewijin Jan 2018

Predictive Simulations Of Gait And Their Application In Prosthesis Design, Anne D. Koelewijin

ETD Archive

Predictive simulations predict human gait by solving a trajectory optimization problem by minimizing energy expenditure. These simulations could predict the effect of a prosthesis on gait before its use. This dissertation has four aims, to show the application of predictive simulations in prosthesis design and to improve the quality of predictive simulations. Aim 1 was to explain joint moment asymmetry in the knee and hip in gait of persons with a transtibial amputation (TTA gait). Predictive simulations showed that an asymmetric gait required less effort. However, a small effort increase yielded a gait with increased joint moment symmetry and reduced ...


Feasibility Of Using An Equilibrium Point Strategy To Control Reaching Movements Of Paralyzed Arms With Functional Electrical Stimulation, Matthew Huffman Jan 2018

Feasibility Of Using An Equilibrium Point Strategy To Control Reaching Movements Of Paralyzed Arms With Functional Electrical Stimulation, Matthew Huffman

ETD Archive

Functional electrical stimulation (FES) is a technology capable of improving the quality of life for those with the loss of limb movement related to spinal cord injuries. Individuals with high-level tetraplegia, in particular, have lost all movement capabilities below the neck. FES has shown promise in bypassing spinal cord damage by sending electrical impulses directly to a nerve or muscle to trigger a desired function. Despite advancements in FES, full-arm reaching motions have not been achieved, leaving patients unable to perform fundamental tasks such as eating and grooming. To overcome the inability in current FES models to achieve multi-joint coordination ...


A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr. Jan 2018

A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr.

ETD Archive

Star polymers are a class of branched polymers comprised of several polymer chains extending from a central point. Star polymers have applications in biopharmaceuticals where they have been proposed to be suitable drug delivery vehicles. Star polymers have traditionally been synthesized through chemical synthesis with added functionality provided by grafting on the arms. This complex synthesis can be simplified by using a biosynthetic approach which enables precise control of molecular weight and composition. This approach is demonstrated using star polymers with arms composed of a temperature responsive protein-based polymer termed elastin-like polypeptide (ELP). Star polymers are characterized based on the ...


Idiosyncratic Drug-Induced Liver Injury (Idili): Potential Mechanisms And Predictive Assays, Alexander D. Roth, Moo-Yeal Lee Jan 2017

Idiosyncratic Drug-Induced Liver Injury (Idili): Potential Mechanisms And Predictive Assays, Alexander D. Roth, Moo-Yeal Lee

Chemical & Biomedical Engineering Faculty Publications

Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver failure (ALF) in the United States. While current drug development processes emphasize general toxicity and drug metabolizing enzyme- (DME-) mediated toxicity, it has been challenging to develop comprehensive models for assessing complete idiosyncratic potential. In this review, we describe the enzymes and proteins that contain polymorphisms believed to contribute to IDILI, including ones that affect phase I and phase II metabolism, antioxidant enzymes, drug transporters, inflammation, and human leukocyte antigen (HLA). We then describe the various assays that have been developed to detect individual reactions ...


C-Jun N-Terminal Kinase Inhibitory Nanotherapeutics For Regenerative Elastic Matrix Repair In Abdominal Aortic Aneurysms, Andrew T. Camardo Jan 2017

C-Jun N-Terminal Kinase Inhibitory Nanotherapeutics For Regenerative Elastic Matrix Repair In Abdominal Aortic Aneurysms, Andrew T. Camardo

ETD Archive

Abdominal aortic aneurysms (AAA) are localized expansions of the aorta wall that continue to grow until they reach a critical size and fatally rupture. This growth is driven by the chronic disruption, degradation, and subsequent loss of aortal wall elastic fibers by matrix metalloproteinases (MMPs) secreted by inflammatory cells recruited to the aorta wall following an injury stimulus, and the inherent inability of vascular smooth muscle cells (SMCs) to naturally repair or regenerate elastic fibers. This leads to a net loss of elastic matrix and the continuing weakening of the aortal wall until eventual rupture. Current treatments seek to reinforce ...


Cathepsin K Targeting Matrix Regenerative Nanoparticles For Small Abdominal Aortic Aneurysm Repair, Jonathan M. Fox Jan 2017

Cathepsin K Targeting Matrix Regenerative Nanoparticles For Small Abdominal Aortic Aneurysm Repair, Jonathan M. Fox

ETD Archive

Abdominal aortic aneurysms (AAAs) are characterized by the loss of elasticity in the aorta wall leading to a chronic increase in diameter and resulting in rupture. This is due to the lack of regeneration of elastic fibers and chronic proteolytic breakdown of elastic fibers within the aorta mediated by matrix metalloproteinases (MMPs), specifically MMP-2 and -9. Previous studies in our lab have shown cationic amphiphile-surface functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with doxycycline (DOX) to inhibit MMP activity and stimulate elastic matrix synthesis, effects we attributed to both low doses (< 10 mg/ml) of DOX released and independent effects of cationic amphiphile pendant groups on the NP surface. This promises application of these NPs to arrest or regress AAA growth since high oral DOX dosing inhibits new elastic matrix formation in the AAA wall and has undesirable side effects. In this study, we investigated feasibility of antibody-based active targeting of intravenously infused NPs to the AAA wall. Cathepsin K, a cysteine protease, is a biomarker for AAA and overexpressed in abdominal aortic aneurysm tissue making it an ideal target moiety. We have shown using a covalent conjugation method of modifying the surface of the NPs with a cathepsin K antibody resulted in a more robust antibody attachment which did not affect the DOX release profile. Cathepsin K expression was confirmed to be localized on the cell surface and utilizing cathepsin K Ab-conjugated NPs, we demonstrated an increased NP localization to the cathepsin K overexpressing cells in vitro and ex vivo. Importantly, the DOX-loaded NPs demonstrated pro-elastogenic and anti-proteolytic effects in aneurysmal smooth muscle cells supporting their use as regenerative therapies to arrest and regress AAA growth. Preliminary data has been collected indicating cathepsin K Ab-conjugated NP targeting to AAAs in elastase-injured rat models. The study outcomes support the feasibility of using cathepsin K Ab-conjugated NPs as a targeted therapy for elastic matrix regeneration in AAA tissue and will serve as a basis for already initiated follow up studies to assess NP biodistribution, in situ retention in the AAA wall, and safety as a function of time.


Design And Control Of A Powered Rowing Machine With Programmable Impedance, Jose Humberto De La Casas Zolezzi Jan 2017

Design And Control Of A Powered Rowing Machine With Programmable Impedance, Jose Humberto De La Casas Zolezzi

ETD Archive

Due to the rise of obesity, diabetes and cardiovascular disease, research in human performance and physical activity has received increased attention. Rowing machines are used for performance improvements through concentric exercises, however a combination of concentric and eccentric actions is known to improve the effectiveness of training. In this work, a conventional rowing machine was modified to include an electric motor and a robust impedance control system, enabling programmable impedance with concentric and eccentric capabilities. Eccentric exercises are known to contribute significantly to the efficacy of training and to diminish the detrimental effects of humans operating in microgravity for long ...


Methodological Considerations Of Electron Spin Resonance Spin Trapping Techniques For Measuring Reactive Oxygen Species Generated From Metal Oxide Nanomaterials, Min Sook Jeong, Kyeong-Nam Yu, Hyun Hoon Chung, Soo Jin Park, Ah Young Lee, Mi Ryoung Song, Myung-Haing Cho, Jun Sung Kim May 2016

Methodological Considerations Of Electron Spin Resonance Spin Trapping Techniques For Measuring Reactive Oxygen Species Generated From Metal Oxide Nanomaterials, Min Sook Jeong, Kyeong-Nam Yu, Hyun Hoon Chung, Soo Jin Park, Ah Young Lee, Mi Ryoung Song, Myung-Haing Cho, Jun Sung Kim

Chemical & Biomedical Engineering Faculty Publications

Qualitative and quantitative analyses of reactive oxygen species (ROS) generated on the surfaces of nanomaterials are important for understanding their toxicity and toxic mechanisms, which are in turn beneficial for manufacturing more biocompatible nanomaterials in many industrial fields. Electron spin resonance (ESR) is a useful tool for detecting ROS formation. However, using this technique without first considering the physicochemical properties of nanomaterials and proper conditions of the spin trapping agent (such as incubation time) may lead to misinterpretation of the resulting data. In this report, we suggest methodological considerations for ESR as pertains to magnetism, sample preparation and proper incubation ...


Decitabine-Loaded Nanogel Treatment To Reverse Cancer Drug Resistance, Samantha A. Cramer Jan 2016

Decitabine-Loaded Nanogel Treatment To Reverse Cancer Drug Resistance, Samantha A. Cramer

ETD Archive

Cancers in which epigenetic changes, such as hypermethylation of DNA, lead to drug resistance cause the cancer to become unresponsive to existing chemotherapeutic treatments. The epigenetic drug – 5-aza-2’-deoxycytidine (decitabine, DAC) – is a potent hypomethylating agent, but its effect is transient due to its instability. Previous studies have shown that loading DAC into nanogel significantly enhances its antiproliferative effect (compared to DAC in solution) in drug-resistant breast cancer cells (MCF-7/ADR). Further, the previous studies demonstrated changes in the membrane lipid profile of resistant cells following treatment with DAC either as solution or in nanogels. The objective of the present ...


Design And Production Of A Hydrogel Forming Polypeptide: Engaging High School Students In Protein Design, James K. Deyling Jan 2016

Design And Production Of A Hydrogel Forming Polypeptide: Engaging High School Students In Protein Design, James K. Deyling

ETD Archive

Bioinks are a class of hydrogel that have the potential to be the ink used in the creation of printed organs, connective tissue, and other important structures within the body. One class of material that may be a suitable bioink hydrogel is elastin-like polypeptides (ELPs), which are synthetic biopolymers inspired by the naturally existing connective tissue elastin. ELPs consist of a repeat pentapeptide sequence (GXGVP)n, where X is any of the 20 naturally existing amino acids other than proline. These biomolecules are capable of exhibiting environmental responsiveness when exposed to certain stimulus such as salt concentration, temperature, and pH ...


Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm Jan 2015

Solute Partitioning In Elastin-Like Polypeptides: A Foundation For Drug Delivery Applications, Eric Helm

ETD Archive

No abstract provided.


Evaluation Of The Performance Of A Downward Flow Inclined Gravity Settler For Algae Dewatering, Dustin D. Bowden Jan 2015

Evaluation Of The Performance Of A Downward Flow Inclined Gravity Settler For Algae Dewatering, Dustin D. Bowden

ETD Archive

With recent concerns over the environmental implications of burning fossil fuels coupled with the depletion of fossil fuel reserves an alternative source of energy isneeded. Algae derived biofuels may be an effective replacement for transportation fuels as they are carbon neutral and have a high area productivity. Algae is superior to terrestrial plants as a biofuel source due to its high oil productivity and efficiency along with the fact that it will not displace food production. Currently the largest obstacle to the implementation of commercial algae to biofuel processes is algae dewatering. The separation of algae from water is difficult ...


Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak Jan 2015

Determining The Transport Enhancement Of Sodium Fluorescein In Mechanically-Loaded Canine Tibia, Andrew Joseph Zak

ETD Archive

Quantitative research concerning the impact of mechanical loading on the transport properties of bone has several critical applications. One such application is the effect of a microgravity environment, where the lack of mechanical forces on bone has been shown to negatively impact both growth and repair. A method has been developed in our lab that can potentially allow for the measurement of the effective permeability of large molecules (i.e., 300-15,000 Da in size) in bone tissue under both unloaded and mechanically loaded conditions. In proof-of-concept experiments, previous students have measured the effective diffusivity of the model solute, sodium ...


Time And Temperature Dependent Surface Tension Measurements Of Responsive Protein-Based Polymer Surfactant Solutions, Hakan Celik Jan 2015

Time And Temperature Dependent Surface Tension Measurements Of Responsive Protein-Based Polymer Surfactant Solutions, Hakan Celik

ETD Archive

A three-armed star elastin-like polypeptide (ELP-foldon) has thermoreversible character which exhibits phase separation above a transition temperature (Tt) in physiologic salt concentrations. At lower salt concentration, the ELP-foldon behaves like a thermoresponsive surfactant, exhibiting micelle formation above its Tt. The purpose of this study is characterize the surfactant behavior of the ELP-foldon at air-liquid interface by measuring the surface tension. The surface tension is measured as a function of time for different ELP concentrations from 10 nM to 50 ℗æM and over range of temperatures from 25 to 35 ℗¿ using the axisymmetric drop shape analysis (ADSA). The ADSA is a ...


Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto Jan 2015

Characterization Of Highly Concentrated Elastin-Like Polypeptide Solutions: Rheometric Properties And Phase Separation Analysis, Kevin Michael Otto

ETD Archive

Elastin-like polypeptides (ELPs) are environmentally responsive biopolymers. These protein based polymers are specific in that they exhibit phase separation in response to a number of stimuli. Some of these stimuli include temperature, light, and pH. There are a large number of factors to consider when designing ELP constructs that allow for control of the transitioning behavior, some of which include amino acid sequences, protein concentration, salt concentration, and the polymer chain length. Elastin-like polypeptides are soluble in water at low temperatures, however, upon an increase in temperature, the proteins become insoluble in water and phase separate. This point of temperature ...


3d Cultures Of Human Liver Cell Lines Encapsulated In Puramatrix On A Microarray Chip Platform, Pratap Lama, Alexander D. Roth, Pranav Joshi, Akshata Datar, Moo-Yeal Lee Sep 2014

3d Cultures Of Human Liver Cell Lines Encapsulated In Puramatrix On A Microarray Chip Platform, Pratap Lama, Alexander D. Roth, Pranav Joshi, Akshata Datar, Moo-Yeal Lee

Undergraduate Research Posters 2014

A high-throughput cell printing technology has developed to simulate the liver tissue environment using a hydrogel-based chip platform that has potential to shift in vivo drug toxicity models towards in vitro tests. However, the hydrophobic nature of polystyrene chips is not promoting direct adhesion of hydrogels, which created a problem with spot attachment. The main goal of this research is to create a surface chemistry that helps to attach a peptide-based hydrogel, including PuraMatrix, to a polystyrenebased micropillar chip. Seven analogs of maleic anhydride co-polymers were used to coat the micropillar chip to create a functional surface. Then, six ionic ...


Anatomy-Based Transmission Factors For Technique Optimization In Portable Chest X-Ray, Chris L. Liptak, W. Paul Segars, Ashraf G. Morgan, Frank F. Dong, Xiang Li Sep 2014

Anatomy-Based Transmission Factors For Technique Optimization In Portable Chest X-Ray, Chris L. Liptak, W. Paul Segars, Ashraf G. Morgan, Frank F. Dong, Xiang Li

Undergraduate Research Posters 2014

Currently, portable x-ray examinations do not employ automatic exposure control (AEC). To aid in the design of a size-specific technique chart, acrylic slabs of various thicknesses are often used to estimate x-ray transmission factors for patients of various body thicknesses. This approach, while simple, does not account for patient anatomy, tissue heterogeneity, and the attenuation properties of the human body. To better account for these factors, in this work, we determined x-ray transmission factors using computational patient models that are anatomically realistic. A Monte Carlo program was developed to model a portable x-ray system. Detailed modeling was done of the ...


Monitoring Micelle Formation In Mixtures Of Linear And Foldon-Capped Polypeptides With Light Scattering Spectroscopy, Janna Mino, John P. Gavin, Michael G. Price, Kiril Streletzky, Nolan Holland Sep 2014

Monitoring Micelle Formation In Mixtures Of Linear And Foldon-Capped Polypeptides With Light Scattering Spectroscopy, Janna Mino, John P. Gavin, Michael G. Price, Kiril Streletzky, Nolan Holland

Undergraduate Research Posters 2014

Elastin-like polypeptide (ELP) polymers are ideal for producing environmentally responsive micellar systems because they exhibit a transition from being water-soluble at low temperatures to phase-separated at high temperatures. For application development of drug delivery vehicles and biosensing nanoparticles, it is important to prepare spherical micelles of controlled diameter and shape. Since at a given salt concentration, the headgroup area for each foldon should be constant, the size of the micelles is expected to be proportional to the volume of the linear ELP available per foldon headgroup. Therefore, adding linear ELPs to a system of ELP-foldon should result in changes of ...


Comparison Of Electronic And Mechanical Handgrip Devices In Lowering Blood Pressure, Katie Webb, Brandon Musarra, Megan O’Keefe, Shana Strunk, Courtney Perkins, Kenneth E. Sparks, Emily Kullman, Eddie T.C. Lam Sep 2014

Comparison Of Electronic And Mechanical Handgrip Devices In Lowering Blood Pressure, Katie Webb, Brandon Musarra, Megan O’Keefe, Shana Strunk, Courtney Perkins, Kenneth E. Sparks, Emily Kullman, Eddie T.C. Lam

Undergraduate Research Posters 2014

Hypertension causes billions of deaths per year (Millar et al., 2013). The Zona PlusTM is an expensive tool designed to lower blood pressure (BP) using isometric exercise. This exercise may be achieved using a less expensive Handgrip Dynamometer. PURPOSE: The purpose of this research is to determine if the Zona or Handgrip Dynamometer is more efficient at lowering BP and most cost effective for patients. METHODS: Twenty subjects used the Zona and twenty subjects used the dynamometer three times per week for six weeks. BP was taken once per week prior to the treatment. A maximum voluntary contraction (MVC) was ...


Validation Of An Accelerometry Based Method Of Human Gait Analysis, Obinna Nwanna Jan 2014

Validation Of An Accelerometry Based Method Of Human Gait Analysis, Obinna Nwanna

ETD Archive

Gait analysis is the quantification of locomotion. Understanding the science behind the way we move is of interest to a wide variety of fields. Medical professionals might use gait analysis to track the rehabilitation progress of a patient. An engineer may want to design wearable robotics to augment a human operator. Use cases even extend into the sport and entertainment industries. Typically, a gait analysis is performed in a highly specialized laboratory containing cumbersome expensive equipment. The process is tedious and requires specially trained operators. Continued development of small and cheap inertial measurement units (IMUs) over an alternative to current ...