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Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
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- 3D culture system (1)
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- Bioreactors (1)
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- Limited Mixing (1)
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- Skull flexure (1)
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- FIU Electronic Theses and Dissertations (3)
- Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research (1)
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- Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research (1)
- Department of Mechanical and Materials Engineering: Faculty Publications (1)
Articles 1 - 7 of 7
Full-Text Articles in Biomedical Engineering and Bioengineering
A Highly Adaptive And Cost Effective Second Generation Incubator (Sgi) Towards Educational, Research And Clinical Processes, Yassir H. Al-Sayagh
A Highly Adaptive And Cost Effective Second Generation Incubator (Sgi) Towards Educational, Research And Clinical Processes, Yassir H. Al-Sayagh
Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research
Today´s rising demand for more reliable and affordable alternatives to organ transplant has led to a growing market for in vitro tissue culture systems. The main objective of tissue engineering as a whole is to employ human tissue equivalents for commercial use. The state-of-the-art processes for producing these so called tissue models are still very expensive, difficult to produce and time-consuming.
To engineer tissues, in vitro, a three-dimensional support structure commonly termed scaffold is needed. Stem cells are then added to the scaffold. In order for tissue to materialize, the scaffold and the cells must be incubated (cultured) at a …
Movement Effects On The Flow Physics And Nutrient Delivery In Engineered Valvular Tissues, Manuel Salinas
Movement Effects On The Flow Physics And Nutrient Delivery In Engineered Valvular Tissues, Manuel Salinas
FIU Electronic Theses and Dissertations
Mechanical conditioning has been shown to promote tissue formation in a wide variety of tissue engineering efforts. However the underlying mechanisms by which external mechanical stimuli regulate cells and tissues are not known. This is particularly relevant in the area of heart valve tissue engineering (HVTE) owing to the intense hemodynamic environments that surround native valves. Some studies suggest that oscillatory shear stress (OSS) caused by steady flow and scaffold flexure play a critical role in engineered tissue formation derived from bone marrow derived stem cells (BMSCs). In addition, scaffold flexure may enhance nutrient (e.g. oxygen, glucose) transport. In this …
Neuromuscular Changes In Older Adults During The Lateral Step Task, Tatiana Bejarano
Neuromuscular Changes In Older Adults During The Lateral Step Task, Tatiana Bejarano
FIU Electronic Theses and Dissertations
Older adults may have trouble when performing activities of daily living due to decrease in physical strength and degradation of neuromotor and musculoskeletal function. Motor activation patterns during Lateral Step Down and Step Up from 4-inch and 8-inch step heights was assessed in younger (n=8, 24.4 years) and older adults (n=8, 58.9 years) using joint angle kinematics and electromyography of lower extremity muscles. Ground reaction forces were used to ascertain the loading, stabilization and unloading phases of the tasks. Older adults had an altered muscle activation sequence and significantly longer muscle bursts during loading for the tibialis anterior, gastrocnemius, vastus …
Experimental And Numerical Investigation Of The Mechanism Of Blast Wave Transmission Through A Surrogate Head, Yi Hua, Praveen Akula, Linxia Gu, Jeff Berg, Carl A. Nelson
Experimental And Numerical Investigation Of The Mechanism Of Blast Wave Transmission Through A Surrogate Head, Yi Hua, Praveen Akula, Linxia Gu, Jeff Berg, Carl A. Nelson
Department of Mechanical and Materials Engineering: Faculty Publications
This work is to develop an experiment-validated numerical model to elucidate the wave transmission mechanisms through a surrogate head under blast loading. Repeated shock tube tests were conducted on a surrogate head, i.e., water-filled polycarbonate shell. Surface strain on the skull simulant and pressure inside the brain simulant were recorded at multiple locations. A numerical model was developed to capture the shock wave propagation within the shock tube and the fluid-structure interaction between the shock wave and the surrogate head. The obtained numerical results were compared with the experimental measurements. The experiment-validated numerical model was then used to further understand …
Developing Defined And Scalable 3d Culture Systems For Culturing Human Pluripotent Stem Cells At High Densities, Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer
Developing Defined And Scalable 3d Culture Systems For Culturing Human Pluripotent Stem Cells At High Densities, Yuguo Lei, Daeun Jeong, Jifang Xiao, David V. Schaffer
Department of Chemical and Biomolecular Engineering: Faculty Publications
Human pluripotent stem cells (hPSCs)—including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs)—are very promising candidates for cell therapies, tissue engineering, high throughput pharmacology screens, and toxicity testing. These applications require large numbers of high quality cells; however, scalable production of human pluripotent stem cells and their derivatives at a high density and under well-defined conditions has been a challenge. We recently reported a simple, efficient, fully defined, scalable, and good manufacturing practice (GMP) compatible 3D culture system based on a thermoreversible hydrogel for hPSC expansion and differentiation. Here, we describe additional design rationale and characterization of this …
Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman
Application Of Limited Mixing In The Hele-Shaw Geometry In Fabrication Of Janus Hydrogels, Md Mahmudur Rahman
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
It is widely accepted that cells behave differently responding to the stiffness of their extracellular matrix (ECM). Such observations were made by culturing cells on hydrogel substrates of tunable stiffness. However, it was recently proposed that cells may sense how strongly they are tethered to ECM, not the local stiffness of ECM. To investigate both hypotheses, we developed a method to fabricate Janus polyacrylamide (PAAM) gels. We squeeze two drops of different concentrations in the Hele-Shaw geometry to generate radial Stokes flow. When the drops coalesce, limited mixing occurs at the interface due to the narrow confinement, and diffusion normal …
Investigating The Role Of A Less Uranium Tolerant Strain, Isolated From The Hanford Site Soil, On Uranium Interaction In Polyphosphate Remediation Technology, Paola Sepulveda Medina
Investigating The Role Of A Less Uranium Tolerant Strain, Isolated From The Hanford Site Soil, On Uranium Interaction In Polyphosphate Remediation Technology, Paola Sepulveda Medina
FIU Electronic Theses and Dissertations
Bacteria are key players in the processes that govern fate and transport of contaminants. Previous assessment showed that the Arthrobacter oxydans (A.oxydans) G968 strain has a lower ability to tolerate U(VI) toxicity in bicarbonate-free media compared to other isolate A.oxydans G975. The study experimentally investigated several parameters such as the potential of bicarbonate to accelerate U(VI) release from autunite mineral in the presence of a less U(VI) tolerant bacterial strain, in the conditions mimicking Hanford Site subsurface environments. Results showed that despite morphological differences between the two bacterial strains, A.oxydans G968 and G975, they are able to dissolute uranium at …