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Biomedical Engineering and Bioengineering Commons™
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- Pure sciences (3)
- Affymetrix microarray images (1)
- Applied math (1)
- Applied sciences (1)
- Bioheat transfer (1)
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- Biological sciences (1)
- Biophysics (1)
- Control theory (1)
- Cylindrical skin (1)
- Disease diagnostics (1)
- High-order finite difference (1)
- Image segmentation (1)
- Laser irradiation (1)
- Microarray (1)
- Optimization (1)
- Pennes' bioheat transfer (1)
- Predictive modeling (1)
- Segmentation based contours (1)
- Triple-layered skin structure (1)
Articles 1 - 4 of 4
Full-Text Articles in Biomedical Engineering and Bioengineering
Modeling And Control Of Nanoparticle Bloodstream Concentration For Cancer Therapies, Scarlett S. Bracey
Modeling And Control Of Nanoparticle Bloodstream Concentration For Cancer Therapies, Scarlett S. Bracey
Doctoral Dissertations
Currently, the most commonly used treatments for cancerous tumors (chemotherapy, radiation, etc.) have almost no method of monitoring the administration of the treatment for adverse effects in real time. Without any real time feedback or control, treatment becomes a "guess and check" method with no way of predicting the effects of the drugs based on the actual bioavailability to the patient's body. One particular drug may be effective for one patient, yet provide no benefit to another. Doctors and scientists do not routinely attempt to quantifiably explain this discrepancy. In this work, mathematical modeling and analysis techniques are joined together …
New Microarray Image Segmentation Using Segmentation Based Contours Method, Yuan Cheng
New Microarray Image Segmentation Using Segmentation Based Contours Method, Yuan Cheng
Doctoral Dissertations
The goal of the research developed in this dissertation is to develop a more accurate segmentation method for Affymetrix microarray images. The Affymetrix microarray biotechnologies have become increasingly important in the biomedical research field. Affymetrix microarray images are widely used in disease diagnostics and disease control. They are capable of monitoring the expression levels of thousands of genes simultaneously. Hence, scientists can get a deep understanding on genomic regulation, interaction and expression by using such tools.
We also introduce a novel Affymetrix microarray image simulation model and how the Affymetrix microarray image is simulated by using this model. This simulation …
A Numerical Method For Obtaining An Optimal Temperature Distribution In A 3d Triple-Layered Cylindrical Skin Structure, Le Zhang
Doctoral Dissertations
In recent years, it has been interesting to research hyperthermia combined with radiation and cytotoxic drugs to enhance the killing of tumors. The crucial problem is that when heating the tumor tissues, one needs to keep the surrounding normal tissue below a temperature that will produce harm. Thus, it is important to obtain the temperature field of the entire treatment region. The objective of this dissertation is to develop a numerical model for obtaining an optimal temperature distribution in a 3D triple-layered cylindrical skin structure. To this end, we pre-specify the temperatures to be obtained at the center and perimeter …
A High -Order Finite Difference Method For Solving Bioheat Transfer Equations In Three-Dimensional Triple -Layered Skin Structure, Haofeng Yu
Doctoral Dissertations
Investigations on instantaneous skin burns are useful for an accurate assessment of burn-evaluation and for establishing thermal protections for various purposes. Meanwhile, hyperthermia with radiation is important in the treatment of cancer, and it is essential for developers and users of hyperthermia systems to predict, and interpret correctly the biomass thermal and vascular response to heating. In this dissertation, we employ the well-known Pennes' bioheat transfer equation to predict the degree of skin burn and the temperature distribution in hyperthermia cancer treatment.
A fourth-order compact finite difference scheme is developed to solve Pennes' bioheat transfer equation in a three-dimensional single …