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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker Aug 2018

Developing Strategies To Toughen Bio-Inspired Adhesives, Narelli P. Narciso, Samuel Lee Huntington, Jonathan J. Wilker

The Summer Undergraduate Research Fellowship (SURF) Symposium

Mussels and other marine creatures adhere very well in underwater environments, having the ability to withstand the force of the sea. These animals have inspired synthetic biomimetic adhesives for wet systems, presenting potential for biomedical applications. However, most current commercial adhesives tend to be brittle, not resisting repetitive movements. This study assesses toughening strategies to improve the mussel-inspired adhesives’ ductility while maintaining its strength. The strategies included altering the polymer’s chemical structure by changing the percentage of polyethylene glycol (PEG) in the molecule and by adding fillers, such as calcium carbonate, silica and nacre - a calcium carbonate compound found …


Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura Oct 2016

Fluorescent Materials Design At Nanoscale For Biomedical Photonics In Near Infrared Window, Kohei Soga, Masao Kamimura

The 8th International Conference on Physical and Numerical Simulation of Materials Processing

No abstract provided.


Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs Aug 2015

Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz …


Adsorption Mechanisms Of Palladium On The Tobacco Mosaic Virus Surface, Gloriia D. Novikova, Oluwamayowa Adigun, Erin Retzlaff-Roberts, Michael T. Harris Aug 2015

Adsorption Mechanisms Of Palladium On The Tobacco Mosaic Virus Surface, Gloriia D. Novikova, Oluwamayowa Adigun, Erin Retzlaff-Roberts, Michael T. Harris

The Summer Undergraduate Research Fellowship (SURF) Symposium

Organic-inorganic materials synthesis using biological templates has recently drawn immense attention of researchers. Biotemplating has shown to be an efficient and economic means of nanomaterials production. Naturally stable, readily available and genetically malleable, Tobacco Mosaic Virus (TMV) is one of the most extensively studied and characterized biotemplates. Particularly, templated synthesis using TMV has produced high quality nanorods and nanowires that have been applied to batteries, memory devices and catalysis. The fundamental mechanisms, governing the adsorption of palladium on the TMV Wild Type and genetically modified versions (TMV1Cys and TMV2Cys), are not fully understood; this knowledge, however, is essential for future …


Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu Aug 2014

Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Due to the high prevalence of arthritis and cartilage-related injuries, tissue engineers are studying ways to grow cartilage tissue replacements. Resilin, an elastomeric protein found in insect cuticles, is known for its extraordinary resilience and elasticity. In previous studies, recombinant resilin-based hydrogels, or cross-linked protein networks, exhibited potential for use in cartilage tissue scaffolds. Our lab successfully developed resilin-based proteins with a sequence based on the mosquito gene and showed that resilin-based hydrogels possess mechanical properties of the same order of magnitude as native articular cartilage. In addition, these mechanical properties can be controlled by changing the protein concentration. To …


Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr. Aug 2014

Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Satellite cells are anatomically localized along the surface of muscle fibers and have been regarded as a population of muscle-specific progenitors that are responsible for muscle regeneration. In response to muscle injuries, satellite cells are activated to enter the cell cycle, then proliferate and differentiate into mature muscle cells to regenerate damaged myofibers. Unfortunately, this natural repair mechanism is interrupted in conditions such as muscle degenerative diseases or volumetric muscle loss. The function of stem cells is regulated by signals from their local microenvironment which is called the stem cell niche. Current satellite cell-based strategies such as direct cell transplantation …


The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu Aug 2014

The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu

The Summer Undergraduate Research Fellowship (SURF) Symposium


Amperometric lactate biosensors are used to detect lactate concentration in blood and tissues, which is integral in identifying cyanide poisoning, septic shock, and athletic condition. The construction of lactate biosensors with high sensitivity, selectivity, and stability is imperative to diagnose and determine these medical conditions. Lactate detection is currently limited to oxygen-rich environments due to the fact that oxygen is a limiting factor in the lactate reaction. To circumvent this problem, researchers have developed mediators or alternate, oxygen-free enzymes to improve sensitivity. In our study, ceria (CeO2) with high oxygen storage capacity (OSC) was introduced to the enzyme …


Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang Aug 2014

Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges. …


Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu Oct 2013

Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bioabsorbable materials are fairly new and proper alloys for implantation in the body have not yet been established. There are a few polymers that have showed promise, but they do not provide the proper mechanical support that metal does. These materials would be used to create devices such as blood stents and orthopedic screws. Investigation into the properties of different alloys can help to establish a material that can be used for implanted devices that are only needed for a limited amount of time. In order to investigate these alloys many different experiments will to be run to test the …