Biomedical Engineering and Bioengineering Commons^™

De Novo Design Of Self-Assembled Hexapeptides As Β-Amyloid (Aβ) Peptide Inhibitors, Jie Zheng, Ge Zhang, Mingzhen Zhang, Qiuming Wang, Guizhao Liang, Mingzhen Zhang, Jun Zhao, Kunal Patel, Xiang Yu, Chao Zhao, Binrong Ding, Feimeng Zhou

Ge Zhang

The ability of peptides to construct specific secondary structures provides a useful function for biomaterial design that cannot be achieved with traditional organic molecules and polymers. Inhibition of amyloid formation is a promising therapeutic approach for the treatment of neurodegenerative diseases. Existing peptide-based inhibitors are mainly derived from original amyloid sequences, which have very limited sequence diversity and activity. It is highly desirable to explore other peptide-based inhibitors that are not directly derived from amyloid sequences. Here, we develop a hybrid high-throughput computational method to efficiently screen and design hexapeptide inhibitors against amyloid-β (Aβ) aggregation and toxicity from the first …