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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Biocompatible Flavone-Based Fluorogenic Probes For Quick Wash-Free Mitochondria! Imaging In Living Cells, Bin Liu, Mickey Shah, Ge Zhang, Qin Liu, Yi Pang
Biocompatible Flavone-Based Fluorogenic Probes For Quick Wash-Free Mitochondria! Imaging In Living Cells, Bin Liu, Mickey Shah, Ge Zhang, Qin Liu, Yi Pang
Ge Zhang
Mitochondria, vital organelles existing in almost all eukaryotic cells, play a crucial role in energy metabolism and apoptosis of aerobic organisms. In this work, we report two new flavone-based fluorescent probes, MC-Mito1 and MC-Mito2, for monitoring mitochondria in living cells. These two probes exhibit remarkably low toxicity, good cell permeability, and high specificity; these probes complement the existing library of mitochondrial imaging agents. The new dyes give nearly no background fluorescence, and their application does not require tedious postwashing after cell staining. The appreciable tolerance of MC-Mito2 encourages a broader range of biological applications for understanding the cell degeneration and …
De Novo Design Of Self-Assembled Hexapeptides As Β-Amyloid (Aβ) Peptide Inhibitors, Jie Zheng, Ge Zhang, Mingzhen Zhang, Qiuming Wang, Guizhao Liang, Mingzhen Zhang, Jun Zhao, Kunal Patel, Xiang Yu, Chao Zhao, Binrong Ding, Feimeng Zhou
De Novo Design Of Self-Assembled Hexapeptides As Β-Amyloid (Aβ) Peptide Inhibitors, Jie Zheng, Ge Zhang, Mingzhen Zhang, Qiuming Wang, Guizhao Liang, Mingzhen Zhang, Jun Zhao, Kunal Patel, Xiang Yu, Chao Zhao, Binrong Ding, Feimeng Zhou
Ge Zhang
The ability of peptides to construct specific secondary structures provides a useful function for biomaterial design that cannot be achieved with traditional organic molecules and polymers. Inhibition of amyloid formation is a promising therapeutic approach for the treatment of neurodegenerative diseases. Existing peptide-based inhibitors are mainly derived from original amyloid sequences, which have very limited sequence diversity and activity. It is highly desirable to explore other peptide-based inhibitors that are not directly derived from amyloid sequences. Here, we develop a hybrid high-throughput computational method to efficiently screen and design hexapeptide inhibitors against amyloid-β (Aβ) aggregation and toxicity from the first …