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Biomedical Devices and Instrumentation
The Summer Undergraduate Research Fellowship (SURF) Symposium
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Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa
Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa
The Summer Undergraduate Research Fellowship (SURF) Symposium
Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known …