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Biomedical Engineering and Bioengineering Commons™
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Biomedical Devices and Instrumentation
The Summer Undergraduate Research Fellowship (SURF) Symposium
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- Atherosclerosis (1)
- Bacterial detection (1)
- Biofouling (1)
- Biopotential recording (1)
- Bradycardia (1)
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- Cardiac thrombus (1)
- Fatigue (1)
- Heart Failure (1)
- Heart failure (1)
- High Throughput (1)
- Hydrocephalus (1)
- Implantable devices (1)
- Intracellular sensing (1)
- Intravascular photoacoustic imaging (1)
- Kinematics (1)
- Left ventricle (1)
- Lipid core (1)
- Lipid detection. (1)
- MEMS (1)
- Magnetic microactuators (1)
- Metal-assisted chemical etching (1)
- Microfluidic control (1)
- Nanostructures (1)
- Nerve stimulation (1)
- Phase changing material (1)
- Photolithography (1)
- Point-of-care diagnostic (1)
- Polyimide (1)
- Protein (1)
- Protein Kinase A (1)
Articles 1 - 8 of 8
Full-Text Articles in Biomedical Engineering and Bioengineering
A Proposal For A Wirelessly Powered, Implantable Pressure Sensor And Neural Stimulator For The Control Of Urinary Incontinence, Robert N. Tucker, Christopher J. Quinkert, Pedro P. Irazoqui
A Proposal For A Wirelessly Powered, Implantable Pressure Sensor And Neural Stimulator For The Control Of Urinary Incontinence, Robert N. Tucker, Christopher J. Quinkert, Pedro P. Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
47 to 53 percent of women over the age of 20 suffer from urinary incontinence, often caused by childbirth-related damage to the pelvic nerve. This uncertainty of when bladder voiding will occur causes social anxiety and can compromise quality of life. This study explores one method to restore the ability to sense the need to urinate and prevent unwanted voiding. We propose a device to measure pressure due to bladder content as the difference between pressure in the bladder and pressure in the abdominal cavity. Integrated circuits, biocompatible packaging, and wireless radiofrequency powering allow for a fully implantable device to …
Lipid Detection In Pig Arteries Using Intravascular Photoacoustic Imaging, Jieying Mai, Yingchun Cao, Ayeeshik Kole, Michael Sturek, Ji-Xin Cheng
Lipid Detection In Pig Arteries Using Intravascular Photoacoustic Imaging, Jieying Mai, Yingchun Cao, Ayeeshik Kole, Michael Sturek, Ji-Xin Cheng
The Summer Undergraduate Research Fellowship (SURF) Symposium
Heart disease is the leading cause of death in the United States and worldwide. Each year over 370,000 people died from coronary artery disease in America. As the primary form of coronary artery disease, atherosclerosis behaves as lipid-rich plaque development inside an artery wall. Vulnerable plaques are those prone to rupture, which may result in thrombus or even death. Typical hallmarks of a vulnerable plaque include thin fibrous cap, a large lipid-rich necrotic core and inflammatory infiltrate. The identification and accurate detection of these lipid depositions in the arterial wall is crucial in the diagnosis of atherosclerosis. However, none of …
Development Of Micro-/Nano-Architectures For Intracellular Sensing Platform, Ryan M. Preston, Dae Seung Wie, Chi Hwan Lee
Development Of Micro-/Nano-Architectures For Intracellular Sensing Platform, Ryan M. Preston, Dae Seung Wie, Chi Hwan Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Currently available nanotechnologies are capable of creating various nanostructures in controlled dimensions such as particles (0D), wires (1D), membranes (2D), and cubes (3D) by exploiting “top-down” or “bottom-up” methods. However, there exist limitations to systematically construct hierarchical nanostructures with geometric complexities. This study is focused on developing a novel nanofabrication strategy that can rationally produce a set of hierarchical nanostructures configured with precisely engineered facets, tip shapes, and tectonic motifs. We aim to identify a collection of optimal materials, array layouts, basic components, and nanofabrication techniques for the production of hierarchical nanostructures by exploiting device-grade semiconducting silicon materials. To accomplish …
Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa
Activity Of Protein Kinase A Attached To Magnetic Beads, Kevin P. Lin, Tamara L. Kinzer-Ursem, Mrugesh K. Parasa
The Summer Undergraduate Research Fellowship (SURF) Symposium
Development of high throughput assays is a crucial step in developing more efficient techniques that aid in many important areas of research today such as drug development or identification of protein structure function relationships. Integration of high throughput assays into more research efforts could drastically decrease the time and cost it takes for a new drug to hit the market. Protein Kinase A (PKA) is an extensively studied protein as it is highly upregulated in cancer and is a hot spot for drug targeting. In this work, azide-tagged PKA is covalently attached to magnetic beads using azide-alkyne cycloaddition, a well-known …
Pathway By Which Vagus Nerve Stimulation Of B Fibers Affects Heart Rate, Kelsey Wasilczuk, Matthew Ward, Pedro Irazoqui
Pathway By Which Vagus Nerve Stimulation Of B Fibers Affects Heart Rate, Kelsey Wasilczuk, Matthew Ward, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Heart failure (HF) affects over 5 million adults in the United States. Many HF patients have a high resting heart rate, which is correlated with a high mortality rate. In recent years, vagus nerve stimulation (VNS) has become an increasingly researched therapy to reduce the resting heart rate of HF patients. However, current dosage given during VNS is increased incrementally at the doctor’s office until side effects present themselves in a patient. In addition, the means by which the therapy works is not completely understood. To better understand the therapy’s mechanisms, the right cervical vagus nerve of several Long Evans …
Stimuli Responsive Fluidics Controls On A Paper-Based Bacterial Detection Platform, Siyu Zhao, Elizabeth Phillips, Jacqueline Linnes
Stimuli Responsive Fluidics Controls On A Paper-Based Bacterial Detection Platform, Siyu Zhao, Elizabeth Phillips, Jacqueline Linnes
The Summer Undergraduate Research Fellowship (SURF) Symposium
Infectious diseases are the leading causes of death around the world. Point-of-care devices using nucleic acid amplification are sensitive enough to diagnose these diseases, however, often require complex and time-intensive sample preparation steps that are not integrated with the detection process. A rapid, sensitive, and integrated sample-to-result diagnostic device will permit disease treatment planning at the point-of-care. Paper-based detection assays are a promising platform to integrate the sample preparation and detection, with minimal infrastructure, equipment, and user involvement. To integrate sample preparation with detection on paper-based assays, timing and delivery of sample fluid flow needs to be controlled. Here we …
Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen
Characterization Of Left-Ventricular Thrombus Formation Using High Frequency Ultrasound, Kelsey A. Bullens, Arvin H. Soepriatna, Pavlos P. Vlachos, Craig J. Goergen
The Summer Undergraduate Research Fellowship (SURF) Symposium
Heart failure is a leading cause of death in the United States, and cardiac thrombus, a common morbidity associated with heart failure, significantly increases a patient’s risk of embolic events. The objective of this project is to characterize left-ventricular (LV) thrombus development using high frequency ultrasound imaging in a murine model. C57BL/6J wild-type mice (n=6) were injected intraperitoneally with iron dextran five times a week for six weeks to increase oxidative stress in the heart. Granulocyte-colony stimulating factor (G-CSF) was subcutaneously injected daily during the second week to initiate stem cell migration and stimulate endothelial cell activation, thus increasing the …
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term …