Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Penta-Modal Imaging Platform With Oct- Guided Dynamic Focusing For Simultaneous Multimodal Imaging, Arash Dadkhah
Penta-Modal Imaging Platform With Oct- Guided Dynamic Focusing For Simultaneous Multimodal Imaging, Arash Dadkhah
FIU Electronic Theses and Dissertations
Complex diseases, such as Alzheimer’s disease, are associated with sequences of changes in multiple disease-specific biomarkers. These biomarkers may show dynamic changes at specific stages of disease progression. Thus, testing/monitoring each biomarker may provide insight into specific disease-related processes, which can result in early diagnosis or even development of preventive measures. Obtaining a comprehensive information of biological tissues requires imaging of multiple optical contrasts, which is not typically offered by a single imaging modality. Thus, combining different contrast mechanisms to achieve simultaneous multimodal imaging is desirable. However, this process is highly challenging due to specific optical and hardware requirements for …
Visible Optical Coherence Tomography Based Multimodal Imaging For Quantification Of Retinal Lipofuscin, Zahra Nafar
Visible Optical Coherence Tomography Based Multimodal Imaging For Quantification Of Retinal Lipofuscin, Zahra Nafar
FIU Electronic Theses and Dissertations
Retinal degeneration is the leading cause of irreversible low vision and blindness in the world, that describes conditions characterized by progressive loss of photoreceptors. Retinal Pigment Epithelium (RPE) is located under photoreceptors’ outer segments and plays an important role in the maintenance of photoreceptors by completing the visual cycle and phagocytosis of shed photoreceptor outer segments. Lipofuscin, a byproduct of the visual cycle, is a nondegradable compound that accumulates in the RPE cells and eventually damages the RPE cells and inevitably causes photoreceptor degeneration. Lipofuscin is the major cause of fundus fluorescence that can be detected by Fundus Autofluorescent (FAF) …
Optical Coherence Photoacoustic Microscopy (Oc-Pam) For Multimodal Imaging, Xiaojing Liu
Optical Coherence Photoacoustic Microscopy (Oc-Pam) For Multimodal Imaging, Xiaojing Liu
FIU Electronic Theses and Dissertations
Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are suitable for being combined to achieve multimodal imaging.
In this dissertation, an optical coherence photoacoustic microscopy (OC-PAM) system was developed for in vivo multimodal retinal imaging with a pulsed broadband …