Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Florida International University

Series

Optical Coherence Tomography

Articles 1 - 3 of 3

Full-Text Articles in Biomedical Engineering and Bioengineering

Penta-Modal Imaging Platform With Oct- Guided Dynamic Focusing For Simultaneous Multimodal Imaging, Arash Dadkhah Mar 2021

Penta-Modal Imaging Platform With Oct- Guided Dynamic Focusing For Simultaneous Multimodal Imaging, Arash Dadkhah

FIU Electronic Theses and Dissertations

Complex diseases, such as Alzheimer’s disease, are associated with sequences of changes in multiple disease-specific biomarkers. These biomarkers may show dynamic changes at specific stages of disease progression. Thus, testing/monitoring each biomarker may provide insight into specific disease-related processes, which can result in early diagnosis or even development of preventive measures. Obtaining a comprehensive information of biological tissues requires imaging of multiple optical contrasts, which is not typically offered by a single imaging modality. Thus, combining different contrast mechanisms to achieve simultaneous multimodal imaging is desirable. However, this process is highly challenging due to specific optical and hardware requirements for …


Visible Optical Coherence Tomography Based Multimodal Imaging For Quantification Of Retinal Lipofuscin, Zahra Nafar Mar 2020

Visible Optical Coherence Tomography Based Multimodal Imaging For Quantification Of Retinal Lipofuscin, Zahra Nafar

FIU Electronic Theses and Dissertations

Retinal degeneration is the leading cause of irreversible low vision and blindness in the world, that describes conditions characterized by progressive loss of photoreceptors. Retinal Pigment Epithelium (RPE) is located under photoreceptors’ outer segments and plays an important role in the maintenance of photoreceptors by completing the visual cycle and phagocytosis of shed photoreceptor outer segments. Lipofuscin, a byproduct of the visual cycle, is a nondegradable compound that accumulates in the RPE cells and eventually damages the RPE cells and inevitably causes photoreceptor degeneration. Lipofuscin is the major cause of fundus fluorescence that can be detected by Fundus Autofluorescent (FAF) …


Optical Coherence Photoacoustic Microscopy (Oc-Pam) For Multimodal Imaging, Xiaojing Liu Nov 2016

Optical Coherence Photoacoustic Microscopy (Oc-Pam) For Multimodal Imaging, Xiaojing Liu

FIU Electronic Theses and Dissertations

Optical coherence tomography (OCT) and Photoacoustic microscopy (PAM) are two noninvasive, high-resolution, three-dimensional, biomedical imaging modalities based on different contrast mechanisms. OCT detects the light backscattered from a biological sample either in the time or spectral domain using an interferometer to form an image. PAM is sensitive to optical absorption by detecting the light-induced acoustic waves to form an image. Due to their complementary contrast mechanisms, OCT and PAM are suitable for being combined to achieve multimodal imaging.

In this dissertation, an optical coherence photoacoustic microscopy (OC-PAM) system was developed for in vivo multimodal retinal imaging with a pulsed broadband …